Results 191 to 200 of about 31,268,655 (339)

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367. [PDF]

Br J Clin Pharmacol
Kuemmerle A, Singh N, Gossen D, Janin A, Sharma R, Cahn A, Gibson RA, Menakuru SR, Lambourne E, Dove T, Gamo FJ, Sanz L, Bestgen B, Chalon S.   +13 more
europepmc   +2 more sources

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on phase I data. [PDF]

J Pharmacokinet Pharmacodyn
Bardol M, Henrich A, Sarr C, Mezzalana E, Langenhorst J.   +4 more
europepmc   +1 more source

Food Effect on Oral Bioavailability: Old and New Questions

Clinical pharmacology in drug development, 2017
Jing‐He Yan
semanticscholar   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Prediction of systemic exposure by food effect on a fixed-dose combination of linagliptin and metformin extended-release. [PDF]

Diabetes Obes Metab
Jeon J, Jeon J, Yun HY, Lee S, Chae JW, Kim J.   +5 more
europepmc   +1 more source

Fineli analyses 2024–2025 : Carbohydrates in cooked products

During the update of the National Food Composition Database Fineli (2024–2025), the study focused particularly on changes in carbohydrates in cooked foods.
Finnish Food Authority, Chemistry Unit
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Using a PBPK Model Incorporating Lymphatic Absorption to Predict Food Effect, Multiple Dosing, and Hepatic Impairment of Cannabidiol. [PDF]

Clin Transl Sci
Qian L, Zhou Z.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source