Predicting Food Effect On Oral Drug Absorption For Solubility-Epithelial Membrane Permeation-Limited Cases With Bile Micelle Solubilization. [PDF]
Pharm ResHigashiguchi Y +5 more
europepmc +1 more source
A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects. [PDF]
Front Pharmacol, 2023 Wang F +12 more
europepmc +1 more source
Risk perceptions, risk attitudes and the formation of consumer acceptance of Genetically Modified (GM) food [PDF]
The influence of risk perception and risk attitudes in the process of accepting genetically modified (GM) food is often ignored, and particularly whether both constructs (latent variables) have a combined effect in explaining consumer acceptance ...
Costa-Font, Montserrat, Gil, Jose Maria
core +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
A Phase 1 Study of Ensitrelvir Fumaric Acid Tablets Evaluating the Safety, Pharmacokinetics and Food Effect in Healthy Adult Populations. [PDF]
Clin Drug Investig, 2023 Shimizu R +5 more
europepmc +1 more source
AN ANALYSIS OF HOUSEHOLD FOOD EXPENDITURE SYSTEMS IN TANZANIA [PDF]
This paper analyzes urban and rural food consumption in Tanzania using the Generalized Translog (GTL) expenditure system. We reject a pooled model in favor of two separate urban and rural models.
Mafuru, January M., Marsh, Thomas L.
core +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Food effect risk assessment in preformulation stage using material sparing μFLUX methodology. [PDF]
ADMET DMPK, 2022 Jankovsky C, Tsinman O, Thakral NK.
europepmc +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
A Phase 1 Dose-Escalation, Food Effect, and Drug-Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR-1505, in Healthy Volunteers. [PDF]
Clin Pharmacol Drug DevGupta VK +16 more
europepmc +1 more source