Results 81 to 90 of about 3,075,206 (240)

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Features of specific food hypersensitivity to dairy and cereal products in children with autism spectrum disorder

Бюллетень сибирской медицины, 2018
The aim of the study was to investigate the relationship between food hypersensitivity, inflammation markers and the cytokine profile in children with autism spectrum disorders (ASD).Materials and methods.
N. A. Cherevko, A. V. Skirnevskaya, M. Yu. Rosenstein, P. S. Novikov, O. A. Muraveinik, A. A. Denisov   +5 more
doaj   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

An Integrated Framework Coupling Hierarchical Hyperspectral i‐trait Screening, Gene Identification, and Functional Validation for Genetic Dissection of Salt Tolerance in Cotton

Advanced Science, EarlyView.
An integrated phenomics–genomics framework captures dynamic salt‐stress responses in laboratory‐grown cotton seedlings through time‐series hyperspectral imaging and non‐destructive i‐trait extraction. Hierarchical screening identifies biologically relevant, heritable, and non‐redundant traits for high‐resolution GWAS, identifying GhST7.
Bowei Xu, Le Liu, Mengli Yu, Yuling Guo, Junli Ye, Jun Zhang, Rumeng Zhao, Jiajie Yang, Wanneng Yang, Yameng Xu, Liqiang Fan, Zuoren Yang   +11 more
wiley   +1 more source

Aluminum Ingestion Promotes Colorectal Hypersensitivity in RodentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known.
Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel   +9 more
doaj   +1 more source

Food Pattern, Food Selectivity and Sensory Profile in Autism Spectrum Disorder: An Exploratory Analysis in Chilean Children

Children
Background/Objectives: Introduction: Food selectivity is highly prevalent in children with autism spectrum disorder (ASD) and is associated with sensory hypersensitivity, particularly in oral, olfactory, and tactile domains.
Fernanda Mora, María José Manzur, David Morales-Zepeda, Oscar Flores, Constanza Schwencke, Marcell Leonario-Rodriguez   +5 more
doaj   +1 more source

Chronic fatigue in patients with unexplained self-reported food hypersensitivity and irritable bowel syndrome: validation of a Norwegian translation of the Fatigue Impact Scale

Clinical and Experimental Gastroenterology, 2013
Ragna Lind,1 Arnold Berstad,2 Jan Hatlebakk,1,3 Jørgen Valeur21Department of Medicine, Haukeland University Hospital, Bergen, 2Unger-Vetlesen Institute, Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, 3Department of Clinical Medicine,
Lind R, Berstad A, Hatlebakk J, Valeur J
doaj  

Pharmacokinetics, Effectiveness and Safety of Certolizumab Pegol in Children and Adolescents With Active Juvenile Idiopathic Arthritis: 9+‐Year Results From a Multicenter, Open‐Label Study

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients aged 2 to 17 years with ...
Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Laura Shaughnessy, Saori Shimizu, Paulette Williams, Rocío Lledó‐García, Gauri Utturkar, Baran Ufuktepe, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, the Paediatric Rheumatology International Trials Organisation (PRINTO); the Pediatric Rheumatology Collaborative Study Group (PRCSG), Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Alberto Martini, Daniel L. Lovell, Nicolino Ruperto   +52 more
wiley   +1 more source

Management of Adult Patients with Gastrointestinal Symptoms from Food Hypersensitivity-Narrative Review. [PDF]

J Clin Med, 2022
Kanikowska A, Janisz S, Mańkowska-Wierzbicka D, Gabryel M, Dobrowolska A, Eder P.   +5 more
europepmc   +1 more source