Results 91 to 100 of about 198,065 (294)

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report [PDF]

, 2017
There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine.
Benvenga, S, Centanni, Marco, Sachmechi, I.   +2 more
core   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

The Postural Tachycardia Syndrome (POTS): Pathophysiology, Diagnosis & Management [PDF]

, 2006
Postural tachycardia syndrome (POTS), characterized by orthostatic tachycardia in the absence of orthostatic hypotension, has been the focus of increasing clinical interest over the last 15 years 1. Patients with POTS complain of symptoms of tachycardia,
Raj, Satish R
core   +1 more source

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial [PDF]

, 2016
Background: Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death.
Adamson, Ashley, Barnes, Alison, Brosnahan, Naomi, Ford, Ian, Hollingsworth, Kieren G., Kean, Sharon, Lean, Mike E.J., Leslie, Wilma S., Mathers, John C., McCombie, Louise, McIlvenna, Yvonne, Peters, Carl, Rehackova, Lucia, Rodrigues, Angela, Ross, Hazel, Sattar, Naveed, Sniehotta, Falko F., Taylor, Roy, Thom, George, Zhyzhneuskaya, Sviatlana   +19 more
core   +3 more sources

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice [PDF]

, 2018
Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T.
Akinyeke, Tunde, Alcazar Maganad, Armando, Bading-Taika, Bayissi, Bobe, Gerd, Choie, Jaewoo, L. Miranda, Cristobal, Lione, Lisa, Maier, Claudia S., Ouanesisouk, Michael, Raber, Jacob, Samson Torres, Eileen Ruth, Stevens, Jan F   +11 more
core   +2 more sources

Structural and Functional Properties of Ingredient Composition in Kenkey Preparation: A Review

ChemFoodChem, EarlyView.
This review synthesizes three decades of research on kenkey, a fermented maize staple of West Africa. Examining the structural, functional, and nutritional properties that emerge from traditional fermentation and thermal processing, and identifying priorities for future research toward quality standardization and commercial development. ABSTRACT Kenkey,
Afia Sakyiwaa Amponsah
wiley   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]

, 2016
The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta, Calandra, Ricardo Saul, Huhtaniemi, Ilpo T., Lux, Victoria Adela R., Poutanen, Matti, Ratner, Laura Daniela, Rulli, Susana Beatriz, Stevens, Guillermina   +7 more
core   +1 more source

Learning the Lessons of Premature Discontinuation of Eating Disorder Therapy: Informing Guidelines to Improve Retention

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Around one to two in five patients prematurely disengage from eating disorder therapy. This Forum paper suggests innovative strategies to increase retention and strategies for evaluating these with patients who have eating disorders.
Tracey D. Wade, Ulrike Schmidt
wiley   +1 more source