Biotechnology Progress, EarlyView.Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire +5 more
wiley +1 more source
Committee on Microbiology and Extraneous Materials: Cosmetic Microbiology: Drug- and Device-Related Microbiology: Microbiological Efficacy Testing of Disinfectants: Food Microbiology—Nondairy [PDF]
, 2000 Anthony D. Hitchins +3 more
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Continuous purification of a parvovirus using two aqueous two‐phase extraction steps
Biotechnology Progress, EarlyView.Abstract Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction method that offers low‐cost, continuous‐adaptable virus purification. A two‐step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run ...
Natalie M. Nold +11 more
wiley +1 more source
Impact of Bacterial Injury and Repair in Food Microbiology: its Past, Present and Future
, 1986 Bibek Ray
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Biotechnology Progress, EarlyView.Abstract Shake flasks are one of the most widely used cultivation vessels in biotechnological process development. To improve the process understanding, new technologies have been reported for online monitoring of different parameters like oxygen, pH, or biomass in the last couple of years.
Lara Strehl +4 more
wiley +1 more source
Comparisons of Microbiological Evaluations of Selected Kitchen Areas with Visual Inspections for Preventing Potential Risk of Foodborne Outbreaks in Food Service Operations [PDF]
, 2001 Hailu Kassa +3 more
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Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies
Biotechnology Progress, EarlyView.Abstract For bioprocesses producing live virus, such as enterovirus Coxsackievirus A21, viral titer (infectivity basis) decay rates can exceed 30% within a day. Consequently, harvest timing is paramount. To optimize titer at harvest, a continuous viral product titer model was generated to elucidate kinetics.
Katherine Forrester +4 more
wiley +1 more source
Biotechnology Progress, EarlyView.Using online metabolite data from the first few days of a bioreactor run, the digital shadow can forecast the cell concentration in real‐time with an accuracy of 13% (standard deviation ≈ 6%). These predictions can guide the optimal harvest time of CAR T cells for subsequent re‐infusion into the patient.
Joseph R. Egan +11 more
wiley +1 more source
Microbiological Decontamination of Food Animal Carcasses by Washing and Sanitizing Systems: A Review
, 1992 James S. Dickson, M. E. Anderson
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Dietary effects on the microbiological safety of food [PDF]
, 2001 E. Carol McWilliam Leitch +3 more
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