Results 51 to 60 of about 3,238,785 (313)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Data for in-depth characterisation of the lamb meat proteome from longissimus lumborum

Data in Brief, 2015
This Data article provides Supplementary data related to the research article titled “In-depth characterisation of the lamb meat proteome from longissimus lumborum” by Yu et al. [1].
Tzer-Yang Yu, James D. Morton, Stefan Clerens, Jolon M. Dyer   +3 more
doaj   +1 more source

How may quality asurance systems in food chains include environmental aspects based on life cycle methodology? [PDF]

, 2004
The number of Quality Assurance Systems (QAS) for food products is increasing and so is the topics they cover, from traditional intrinsic product characteristics such as percent meat in slaughtered pigs and protein content in milk to food safety issues ...
Halberg, Niels
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Anti-Oxidative and Anti-Inflammation Activities of Pork Extracts

Food Science of Animal Resources, 2016
This study was conducted to evaluate the antioxidative and anti-inflammatory effects of boiled pork powder (BPP) and hot water extract powder (HWEP) from 4 cuts of meat from Landrace × Yorkshire × Duroc (LYD).
Juae Gil, Dongwook Kim, Seok-Ki Yoon, Jun-Sang Ham, Aera Jang   +4 more
doaj   +1 more source

Genetic identification of a major, novel and stably expressed QTL for effective tiller number from tetraploid wheat

Biotechnology & Biotechnological Equipment, 2021
Effective tiller number (ETN) is an important factor affecting plant architecture and wheat yield. The reduction of genetic diversity in common wheat breeding forces us to explore new genetic resources for ETN from wheat related species to increase wheat
Li Chen, Hua Li, Yanmei Liu, Juan Yang, Ying Hou   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Amine-Functionalized- Mesoporous Silica Nanoparticles by Various Pore Sizes Containing Gallic Acid: Characterization and Cytotoxicity Effect [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Mesoporous Silica Nanoparticles (MSNs) with varying pore sizes of 2.4, 2.44, and 3.44 nm were synthesized and functionalized using 3-aminopropyltriethoxysilane (AP-MSNs), followed by the loading of Gallic Acid (GA) to produce AP-MSNs-GA.
Ladan Rashidi, Ebrahime Vashegani Farahani, Fariba Ganji, Anosheh Rahmani, Mansooreh Mazaheri   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source