Results 61 to 70 of about 6,174,570 (303)

Development and Validation of a Reporter-Cell-Line-Based Bioassay for Therapeutic Soluble gp130-Fc

Molecules, 2019
Soluble glycoprotein 130 kDa (sgp130)-Fc fusion protein, an innovative therapeutic bio-macromolecular drug specifically targeting IL-6 trans-signaling, proved to have good potential for application in the treatment of chronic inflammatory diseases.
Lei Yu, Chuncui Jia, Wenrong Yao, Dening Pei, Xi Qin, Chunming Rao, Junzhi Wang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology

npj Vaccines
Vaccines against SARS-CoV-2 have targeted the spike protein and have been successful at preventing disease. However, with the emergence of variants, spike-specific vaccines become less effective.
Jaekwan Kim, Alla Kachko, Prabhuanand Selvaraj, David Rotstein, Charles Brandon Stauft, Naveen Rajasagi, Yangqing Zhao, Tony Wang, Marian Major   +8 more
doaj   +1 more source

Celiac Disease and Gluten-Free Oats: A Canadian Position Based on a Literature Review

Canadian Journal of Gastroenterology and Hepatology, 2016
This paper provides an overview of the latest scientific data related to the safety of uncontaminated oats (
Sébastien La Vieille, Olga M. Pulido, Michael Abbott, Terence B. Koerner, Samuel Godefroy   +4 more
doaj   +1 more source

Amine-Functionalized- Mesoporous Silica Nanoparticles by Various Pore Sizes Containing Gallic Acid: Characterization and Cytotoxicity Effect [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Mesoporous Silica Nanoparticles (MSNs) with varying pore sizes of 2.4, 2.44, and 3.44 nm were synthesized and functionalized using 3-aminopropyltriethoxysilane (AP-MSNs), followed by the loading of Gallic Acid (GA) to produce AP-MSNs-GA.
Ladan Rashidi, Ebrahime Vashegani Farahani, Fariba Ganji, Anosheh Rahmani, Mansooreh Mazaheri   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Inhibitory Effect of PgAFP and Protective Cultures on Aspergillus parasiticus Growth and Aflatoxins Production on Dry-Fermented Sausage and Cheese

Microorganisms, 2018
Aflatoxigenic molds can grow and produce aflatoxins on dry-fermented meat and cheese. The small, basic, cysteine-rich antifungal protein PgAFP displays a time-limited inhibitory ability against unwanted molds by increasing reactive oxygen species (ROS ...
Josué Delgado, Alicia Rodríguez, Alfredo García, Félix Núñez, Miguel A. Asensio   +4 more
doaj   +1 more source

Task Force report on non-food uses of Kansas agricultural products.

, 1989
"January 1989." "Submitted to Kansas State Board of Agriculture.""As Chairman of the Task Force on the Non-Food Uses of Kansas Agricultural Products, I would like to present the findings gathered during our eight-month study and review.
Task Force on the Non-Food Uses of Kansas Agricultural Products.
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source