Results 71 to 80 of about 3,238,785 (313)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology

npj Vaccines
Vaccines against SARS-CoV-2 have targeted the spike protein and have been successful at preventing disease. However, with the emergence of variants, spike-specific vaccines become less effective.
Jaekwan Kim, Alla Kachko, Prabhuanand Selvaraj, David Rotstein, Charles Brandon Stauft, Naveen Rajasagi, Yangqing Zhao, Tony Wang, Marian Major   +8 more
doaj   +1 more source

Camel milk composition [PDF]

BIO Web of Conferences
This study analyzed the physicochemical properties, amino acid profile, fatty acid composition, and sensory characteristics of camel, cow, and mixed (camel:cow) milk samples.
Boukova Rosica, Balabanova Tatyana, Mollov Plamen, Balabanov Aleksandar   +3 more
doaj   +1 more source

Consumer expectations towards origin-claimed food products. Compensation and acceptance for global trading system [PDF]

Origin- claimed food products mainstream gives diverse features over the world. The food labelling practices based on origin or provenance are frequently developed as a reaction to global trading system: private and NGO's initiatives (Fair Trade ...
Giraud, Georges
core   +1 more source

Primary investigation into the occurrence of Hydroxymethylfurfural (HMF) in a range of smoked products [PDF]

, 2018
5-hydroxymethylfurfural (HMF) is produced in foods through many different pathways. Recently, studies have revealed its potential mutagenic and carcinogenic properties.
Bouzalakou-Butel, Laura-Artemis, Fiore, Alberto, Provatidis, Pantelis, Sturrock, Keith   +3 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

QUANTIFYING REGULATORY BARRIERS TO ASIAN-U.S. FOOD TRADE [PDF]

Data on U.S. Food and Drug Administration import detentions and alerts are used to quantify regulatory barriers experienced by Asian food products entering the United States.
Caswell, Julie A., Wang, Joanne
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Design, Synthesis, and Activity Evaluation of Novel N-benzyl Deoxynojirimycin Derivatives for Use as α-Glucosidase Inhibitors

Molecules, 2019
To obtain α-glucosidase inhibitors with high activity, 19 NB-DNJDs (N-benzyl-deoxynojirimycin derivatives) were designed and synthesized. The results indicated that the 19 NB-DNJDs displayed different inhibitory activities towards α-glucosidase
Fanxin Zeng, Zhongping Yin, Jiguang Chen, Xuliang Nie, Ping Lin, Tao Lu, Meng Wang, Dayong Peng   +7 more
doaj   +1 more source

THE MAKING OF FASHION PRODUCT USING SURFACE TEXTILE DESIGN INSPIRED FROM BANANA LEAF AS BANDUNG TRADITIONAL FOOD WRAPPING [PDF]

, 2019
Nowadays, many fashion products are inspired by the visual from food. This phenomenon is known as food fashion trends. Generally, fast food becomes the main inspiration for this trend.
Bastaman, W. U. (Widia Nur ), Ilhami, F. (Fika )   +1 more
core