Results 61 to 70 of about 21,242,973 (297)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Local Food Systems Food Safety Concerns
Microbiology Spectrum, 2018 ABSTRACT Foodborne disease causes an estimated 48 million illnesses and 3,000 deaths annually (Scallan E, et al., Emerg Infect Dis 17:7–15, 2011), with U.S. economic costs estimated at $152 billion to $1.4 trillion annually (Roberts T, Am J Agric Econ 89:1183–1188, 2007; Scharff RL,
Benjamin, Chapman, Chris, Gunter
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Modeled sustainability impacts of increasing pork consumption among adults in the United States
Frontiers in NutritionIntroductionLittle is known about the role of pork in sustainable diet patterns, given that it is often aggregated with other animal proteins or not evaluated at all.
Zach Conrad +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Rights of the child as imperatives for transforming food systems
Ecology and SocietyEnsuring access to nutritious food, maintaining a healthy planet, and eradicating child labor remain as critical priorities for protecting children’s rights.
Anu Lähteenmäki-Uutela +5 more
doaj +1 more source
The Symbiotic Food System: An ‘Alternative’ Agri-Food System Already Working at Scale
Agriculture, 2016 This article is an analysis of the agri-food system that feeds most of the over four million residents of the fast growing city of Dar es Salaam in Tanzania.
Marc C. A. Wegerif, Paul Hebinck
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ecology and SocietyFood systems are increasingly subject to shocks (e.g., climate change, pandemics, financial or political crises), threatening food supply both locally and globally.
Laurence Jeangros +3 more
doaj +1 more source