Results 71 to 80 of about 161,700 (312)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Proceedings of the workshop ‘Biofortified food - Working together to get more nutritious food to the table in India’

open access: yesJournal of Nutrition & Intermediary Metabolism, 2019
HarvestPlus is the global leader in biofortification and has been leading biofortification efforts in India for nearly a decade. A workshop hosted by HarvestPlus was held in April 2019 in New Delhi to discuss ways to increase the scale, reach and impact ...
Tora Mitra-Ganguli   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Are U.S. Consumers Tolerant of GM Foods? [PDF]

open access: yes
Genetically modified (GM) foods have caused many controversies. One important controversy relates to tolerance?the impurity rate that is tolerated before a commodity must be labeled as genetically modified.
Huffman, Wallace   +3 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Food Loss, Food Waste, and Sustainability in Food Supply Chains

open access: yes
AbstractConsidering that food supply chains are a major part of many discussions about sustainability, it is worrying that a lot of the food that is produced does not actually make it to consumption. This means that related environmental impacts were made in vain, while at the same time food insecurity is a main problem in many parts of the world.
Akkerman, Renzo, Cruijssen, Frans
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Potential of Local Food Use in the Ohio Health Care Industry: An Exploratory Study

open access: yesJournal of Agriculture, Food Systems, and Community Development, 2016
Institutionalized foodservice in health care is evolving. Some hospitals have introduced local foods as a means of improving health and wellness. Investigation into the hospital foodservice literature, however, leaves unclear what percentage of hospitals
Brian Raison, Scott D. Scheer
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Nutrient supply and demand evolution of China’s agri-food system under greater food approach [PDF]

open access: yesZiyuan Kexue
[Objective] This study aims to systematically diagnose the evolution characteristics and inherent contradictions in the nutrient supply and demand of China’s agri-food system from 2000 to 2022, providing a scientific basis for the transformation of the ...
LIANG Yajia, CHEN Kunqiu
doaj   +1 more source

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