Results 41 to 50 of about 4,418,098 (306)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Air Traffic Complexity Analysis in Multi-Airport Terminal Areas Based on Route Segment–Flight State Interdependent Network

Aerospace
An analysis of air traffic complexity in multi-airport terminal areas can assist air traffic controllers in accurately assessing the air traffic situation and collaboratively managing air traffic flows, thereby enhancing the utilization of airspace ...
Chuanlong Zhang, Xiangxi Wen, Minggong Wu, Libiao Zhang, Hanchen Xie, Lingzhong Meng, Jiale Yang   +6 more
doaj   +1 more source

Solution and Optimization of Aircraft Swarm Cooperating Anti-Stealth Formation Configuration

IEEE Access, 2018
There are many problems in present anti-stealth detection technologies, such as small detection range and excessive detection blind zone. Besides, the stealth target is difficult to be detected and tracked with current technology. To solve these problems,
Liping Hu, Peng Bai, Xiaolong Liang, Jiaqiang Zhang, Weijia Wang   +4 more
doaj   +1 more source

Fluid forces control endothelial sprouting [PDF]

Proceedings of the National Academy of Sciences, 2011
During angiogenesis, endothelial cells (ECs) from intact blood vessels quickly infiltrate avascular regions via vascular sprouting. This process is fundamental to many normal and pathological processes such as wound healing and tumor growth, but its initiation and control are poorly understood. Vascular endothelial cell growth factor (VEGF) can promote
Jonathan W, Song, Lance L, Munn
openaire   +2 more sources

Force-Control for the Automated Footwear Testing System [PDF]

, 2005
The Automated Footwear Testing System (AFTS) is a robotic system designed to replicated the movement and loading of a shoe as it contacts the ground during common human movements.
Lewis, Greg
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Correlation coefficients between normal wiggly hesitant fuzzy sets and their applications

Scientific Reports
The multi-criteria decision-making (MCDM) field has long sought tools capable of adeptly capturing the intricacies of human decision-making amidst uncertainty.
Qianzhe Wang, Minggong Wu, Dongwei Zhang, Peng Wang   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Integrated Design of Cooperative Detection and Guidance Considering Equal Numbers of Aircraft on Both Sides

Aerospace
In the scenario where the number of interceptors is equal to the number of target aircraft, and recognizing that the geometric configuration of interceptors during their maneuver towards targets affects detection effectiveness and guidance accuracy, we ...
Jin Wang, Yang Guo, Yongchao Wang, Fucong Liu, Zhengquan Liu, Haonan Wang, Chengyi Zhang   +6 more
doaj   +1 more source