Results 71 to 80 of about 4,418,098 (306)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Hydraulic servo system increases accuracy in fatigue testing [PDF]
, 1967 Hydraulic servo system increases accuracy in applying fatigue loading to a specimen under test. An error sensing electronic control loop, coupled to the hydraulic proportional closed loop cyclic force generator, provides an accurately controlled peak ...
Dixon, G. V., Kibler, K. S.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Evaluation Method of Usability of Low Altitude Airspace ResourcesBased on the Regression Analysis
Hangkong gongcheng jinzhan, 2019 Low altitude airspace resources has always been the development bottleneck of the general aviation industry, and is also one of the key factors in restricting the development of general aviation in China. Based on theoretical research and field research,
Wang Zekun +4 more
doaj +1 more source
Sufficient Conditions Used in Admittance Selection for Planar Force-guided Assembly [PDF]
, 2002 Admittance control approaches show significant promise in providing reliable force-guided assembly. An important issue in the development of these approaches is the specification of an appropriate admittance control law.
Huang, Shuguang, Schimmels, Joseph M.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
DronesAddressing prevalent challenges in current cooperative task assignment methods for cross-domain unmanned swarm, such as the disconnection between decision-making and execution processes, and the inadequate incorporation of platform kinematic constraints,
Aoyu Zheng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
A Spatio-Temporally Cooperative Guidance Law for Highly Maneuverable Target
AerospaceConventional guidance laws often exhibit difficulty in approaching highly maneuverable targets and suffer from poor robustness. To address these limitations, this paper proposes a spatio-temporally consistent cooperative guidance method based on the ...
Jia Liu +5 more
doaj +1 more source
Development of a micromanipulation system with force sensing [PDF]
, 2007 This article provides in-depth knowledge about our undergoing effort to develop an open architecture micromanipulation system with force sensing capabilities.
Khan, Shahzad +6 more
core +2 more sources