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Naloxone Inhibits Clomipramine in Mouse Forced Swimming Test
European Journal of Pharmacology, 1982Naloxone inhibited the effect of clomipramine on duration of immobility of mice in the forced swimming test. This test is proposed as an antidepressant study model. It had previously been shown that naloxone inhibited the analgesic effect of the antidepressant clomipramine.
Alain Eschalier +2 more
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Effect of Pilopool on Forced Swimming Test in Mice
International Journal of Neuroscience, 2008Pilopool is composed of high molecular weight water-soluble chitosan, Allium sativum L. extract, mushroom extract, Dioscorea Batatas D., and purple bamboo salt. This study investigated the effect of Pilopool on performance of forced swimming test (FST).
Hyun-Na, Koo +7 more
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Ethopharmacology of Imipramine in the Forced-Swimming Test: Gender Differences
Neuroscience and Biobehavioral Reviews, 1998Most of the pre-clinical tests used to assay the efficacy of prospective new agents are done with male experimental animals. In this case, a large part of the population is disregarded as is the interaction of the new agent's effects with female hormonal fluctuations.
Helena Maria Tannhauser Barros
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A possible alarm substance in the forced swimming test
Physiology & Behavior, 1990Rats were tested in a forced swimming paradigm under a number of conditions which showed that time of day of testing did not significantly affect duration of immobility and a shorter ten-minute test period was as effective as the traditional longer protocol which tests animals 24 hours after initial immersion.
E L, Abel, P J, Bilitzke
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Neurobehavioral studies of forced swimming: The role of learning and memory in the forced swim test
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19901. Immobility in the forced swim test ("behavioral despair test") has often been regarded as an animal model of despair or depression. 2. Behavioral studies of forced swimming ("behavioral despair") are reviewed and compared with certain behavioral effects of exposure to inescapable shock (i.e., "learned helplessness"). 3. Exposure to inescapable shock
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Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
The Journal of Pharmacology and Experimental Therapeutics, 2005The influence of dosing time on the anti-immobility effect of antidepressants and mechanisms underlying this phenomenon were investigated in mice. In the forced swimming test (FST), the immobility time of mice treated with amitriptyline (15 mg/kg) and fluvoxamine (30 mg/kg) showed a significant 24-h rhythm.
Kentarou, Ushijima +6 more
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Buspirone enhances immobility in the forced swim test in mice
Pharmacology Biochemistry and Behavior, 1996We studied the effects of buspirone and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on duration of immobility in mice in the forced swim test. Buspirone [3-10 mg/kg, intraperitoneally (IP)] potently and dose dependently increased the duration of immobility in mice.
Y, Kitamura, T, Nagatani
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Physiological correlates of the forced swim test in rats
Physiology & Behavior, 1993Rats were tested in the forced swim test to evaluate the effects of duration of exposure (0, 5, 15, or 25 min), and water temperature (0, 35, 30, 25, or 20 degrees C), on a variety of physiological measures. Serum corticosterone, glucose, lactate, phosphorus levels, and the anion gap (a measure of acid-base status) were increased significantly, whereas
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Effect of monoamine precursors on the forced-swimming test in mice
Psychopharmacology, 1988The antidepressant properties of monoamine precursors were evaluated by the forced-swimming test for mice developed by Porsolt et al. DOPA but not 5-hydroxytryptophan (5HTP) shortened immobility at doses that did not increase locomotor activity. Although L-threo-dihydroxyphenylserine (DOPS), an artificial norepinephrine (NE) precursor, did not change ...
J I, Semba, R, Takahashi
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Pharmacological characterization of the forced swim test in Drosophila melanogaster
Invertebrate Neuroscience, 2020The forced swim test is commonly used as a preclinical screen of antidepressant medication efficacy in rats and mice. Neckameyer and Nieto-Romero (Stress 18:254-66, 2015) adopted the forced swim test for use with the fruit fly Drosophila melanogaster and showed that behavior in this test is sensitive to several physiologically relevant stressors ...
Aryana R. Rasti +3 more
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