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Gradient of alarm substance in the forced swimming test
Physiology & Behavior, 1991Three studies were conducted with rats to study the effects of a proposed alarm substance released during the forced swimming test. In the first study, rats were retested in water previously swum in but which had been subsequently diluted to varying degrees.
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An automated analysis of rat behavior in the forced swim test
Pharmacology Biochemistry and Behavior, 2001The Porsolt forced swim test (FST) is a commonly used paradigm to evaluate antidepressant activity of drugs. This test is based on visual measurement of the rat's floating time (FT) in a tank filled with water. Here, we present an automated, accurate and faster method for estimating FT by the distance moved (DM) by the animal via the use of the ...
Hédou, Gaël +4 more
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Role of corticotropin-releasing factor in forced swimming test
European Journal of Pharmacology, 1998Several aspects of the role of corticotropin-releasing factor (CRF) in the forced swimming test were investigated in this study by using two different administration schedules. I.c.v. microinjection of CRF produced a dose-dependent increase in swimming activity when the administration schedule originally reported for this test to screen antidepressant ...
C, García-Lecumberri, E, Ambrosio
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Forced swimming test in mice: a review of antidepressant activity
Psychopharmacology, 2004Among all animal models, the forced swimming test (FST) remains one of the most used tools for screening antidepressants.This paper reviews some of the main aspects of the FST in mice. Most of the sensitivity and variability factors that were assessed on the FST are summarized.We have summarized data found in the literature of antidepressant effects on
Benoit, Petit-Demouliere +2 more
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On the role of endogenous GABA in the forced swimming test in rats
Pharmacology Biochemistry and Behavior, 1988GABA content was reduced in the nucleus accumbens, cortex and brainstem of rats after 5 but not after 45, 120 min or 24 hr, from the termination of the pretest session. This reduction was not observed in rats performing on rotarod. Intraperitoneal AOAA (25 mg/kg; 24, 5 and 1 hr before the test), reduced at the same extent immobility time regardless ...
F, Borsini +4 more
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Is immobility of rats in the forced swim test “behavioral despair?”
Physiology & Behavior, 1988Rats were forced to swim in a cistern until sinking in order to examine the possible relationship between sinking and immobility which has been reported to reflect "behavioral despair" in the forced swim test. Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test.
H, Nishimura +4 more
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Effects of anxiogenic drugs in rat forced swimming test
Methods and Findings in Experimental and Clinical Pharmacology, 1999The effect of antidepressants and anxiogenics in the forced swimming (Porsolt') test was investigated in rats. On the second day of an experiment, desipramine (10 mg/kg), pentylenetetrazole (20 mg/kg), picrotoxin (2.5 mg/kg), and clonidine (1.0 mg/kg) shortened while buspirone (1.0 mg/kg), yohimbine (2.5 mg/kg), DMCM (1.0 mg/kg), and Ro-15-4513 (1.0 mg/
T, Skrebuhhova, L, Allikmets, V, Matto
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The Forced Swim Test for Depression-Like Behavior in Rodents
2018The forced swim test assesses learned helplessness, which is a feature of depression-like behavior in rodents. This test has also been used in testing the efficacy of existing and novel antidepressant drugs. It is based on the natural tendency of rodents to escape from water.
Kraeuter, Ann-Katrin +2 more
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Automated analysis of antidepressants’ effect in the forced swim test
Journal of Neuroscience Methods, 2010The forced swim test (FST) is a commonly used procedure of preclinical screening of drugs for the antidepressant activity. It has high predictive validity for a large group of antidepressant drugs blocking serotonin and noradrenaline reuptakes and improvement of immobility time evaluation in the FST is an important problem of preclinical ...
Alexander V, Kulikov +4 more
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Behavioral effect of herbal glycoside in the forced swimming test
Methods and Findings in Experimental and Clinical Pharmacology, 2002We investigated the behavioral effects of Chinese herbal medicines in the forced swimming test. One of these medicines, Kami-shoyo-san, induced an antidepressive climbing behavior in mice. An effective substance detected to be an O-linked glycoside with the sugar chain structure GalNAc alpha 1-3GalNAc was separated.
Y, Masuda +4 more
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