Results 51 to 60 of about 7,444,069 (295)

Antidepressant effects of valproic acid in an animal model of depression

European Pharmaceutical Journal, 2019
Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was
Buzgoova K., Balagova L., Hlavacova N., Jezova D.   +3 more
doaj   +1 more source

Effect of potassium channel modulators in mouse forced swimming test [PDF]

British Journal of Pharmacology, 1999
The effect of intracerebroventricular (i.c.v.) administration of different potassium channel blockers (tetraethylammonium, apamin, charybdotoxin, gliquidone), potassium channel openers (pinacidil, minoxidil, cromakalim) and aODN to mKv1.1 on immobility time was evaluated in the mouse ...
GALEOTTI, NICOLETTA, GHELARDINI, CARLA, B. CALDARI, BARTOLINI, ALESSANDRO   +3 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The response of glutathione oxidase and cytochrome c to exercise training and sodium selenite in the heart tissue of male rats

Biochemistry and Biophysics Reports
Introduction: Exercise training combined with supplements may be effective in enhancing antioxidant defense and mitochondrial function. Therefore, this study aimed to determine the response of glutathione peroxidase and cytochrome c to forced resistance ...
Farah Nameni, Fatemeh Elikaei
doaj   +1 more source

Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

Bangladesh Journal of Pharmacology, 2015
The advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming
Muhammad Aslam, Nuzhat Sultana
doaj   +1 more source

Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives

Bangladesh Journal of Pharmacology, 2022
The compounds 1,3,4-oxadiazole derivatives (1-8) were synthesized by the cyclization of 4-hydroxy benzhydrazide (1) with various substituted aroma-tic aldehydes (2) using FeCl3 as catalyst and methanol as a solvent medium.
Banylla Felicity Dkhar Gatphoh, Natasha Naval Aggarwal, S. Madan Kumar, M. Vijay Kumar, B. C. Revanasiddappa   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Synchronic Effect of Curcumin and swimming training on depression in morphine addicted male mice

Journal of Medicinal Plants, 2017
Introduction: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal medicine.
L Elhampour, MA Azarbayjani, M Nasehi, M Piri, MR Zarindast   +4 more
doaj  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source