Results 31 to 40 of about 7,444,069 (295)
Molecules, 2016 The synthesis of the tetracyclic compounds 1-(4,5-dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl)-N-methylmethanamine (5) and 1-(1,8-dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl)-N-methylmethanamine (6) as a homologue of the anxiolytic and ...
Usama Karama +3 more
doaj +1 more source
Antidepressant Potential of Diphenyl Dimethyl Bicarboxylate (DDB) in a Modified Forced Swimming Test
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Biphenyl Dimethyl Dicarboxylate (DDB); is an analogue of schisandrin C, a component isolated from Fructus Schisandrae Chinensis. It is now attracting growing attention for its polypharmacotherapeutic properties as an antiviral, hepatoprotective, and ...
Amal Mahfoz
doaj +1 more source
Forced swimming test and mechanisms of depression [PDF]
, 2015 Depression is a severe psychical disorder belonging to affective disorders. Nowadays, it belongs to the most common psychical disorders and prevalence is between 5 % to 16 %. An animal research is essential to study mechanisms of depression.
Janďourková, Pavla
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Envolvimento do sistema monoaminérgico no efeito antidepressivo do extrato das folhas de Schinus Molle L. em camundongos [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Schinus molle L. (Anacardiaceae), among other uses, is popularly employed for the treatment of depression.
Machado, Daniele Guilhermano
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2021 Objective: Recent evidence suggests that quercetin, which has the structure 3,3’,4’,5,7-pentahydroxyflavone, exhibits several central nervous system (CNS)-related activities like antinociception and cognitive enhancementas well as antidepressant-like ...
Feyza Alyu +2 more
doaj
Pharmaceuticals, 2023 Hypothyroidism is closely related to mental disorders, mainly depression, through an as-yet-unknown mechanism. The cerebral inflammatory immune process has been implied to play a pivotal role in the onset of affective symptoms in several conditions.
Yizhen Wang +4 more
doaj +1 more source
Modulação do comportamento de ratos submetidos ao teste do nado forçado pelo receptor vanilóide de potencial transitório tipo 1 do hipocampo [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA depressão é um sério transtorno do humor que acomete grande parte da sociedade atual. O hipocampo é uma das regiões
Vanvossen, Ana Carolina
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source