Results 71 to 80 of about 185,793 (320)
Advanced Science, EarlyView.A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra +23 more
wiley +1 more source
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
Biology Open, 2012 Summary Holoprosencephaly is the most common forebrain defect in humans. We describe two novel mouse mutants that display a holoprosencephaly-like phenotype.
David M. McKean, Lee Niswander
doaj +1 more source
Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype [PDF]
, 2004 The LIM homeodomain family of transcription factors is involved in many processes in the developing CNS, ranging from cell fate specification to connectivity.
Alifragis, P, Liapi, A, Parnavelas, JG
core +1 more source
Wnt Signaling and Forebrain Development [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Components of the Wnt signaling pathway are expressed in a tightly regulated and spatially specific manner during development of the forebrain, and Wnts are key regulators of regional forebrain identity. Wnt signaling from the cortical hem regulates the expansion and cell-type specification of the adjacent neuroepithelium and, in conjunction with Bmp ...
Harrison-Uy, Susan J, Pleasure, Samuel J
openaire +4 more sources
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. [PDF]
, 2019 Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition ...
Garcia-Junco-Clemente, Pablo +3 more
core +1 more source
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, EarlyView.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
First Natural Endocranial Cast of a Fossil Snake (Cretaceous of Patagonia, Argentina) [PDF]
, 2017 In this study, we describe a natural endocranial cast included in a partially preserved medium‐sized skull of the Upper Cretaceous South American snake Dinilysia patagonica.
Albino, Adriana Maria +3 more
core +2 more sources
Construction of the human forebrain [PDF]
WIREs Cognitive Science, 2016 The adult human brain is arguably the most complex of biological systems. It contains 86 billion neurons (the information processing cells of the brain) and many more support cells. The neurons, with the assistance of the support cells, form trillions of connections creating complex, interconnected neural networks that support all human thought ...
Jernigan, Terry L, Stiles, Joan
openaire +4 more sources