Results 51 to 60 of about 2,840,488 (300)

Forensic Analysis and a New Investigation into the Death of the Czechoslovak Minister of Foreign Affairs in 1948

, 2022
This paper describes the political, social and historical situation in Czechoslovakia in the year 1948 when the body of the minister of foreign affairs was found in the courtyard of the Ministry of Foreign Affairs at Černín Palace.
Čermák, Martin, Špička, Jan
core  

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice

Journal of Neuroinflammation
Methamphetamine (METH) abuse, a global public health concern, is closely linked to neuropsychiatric disorders such as depression. Although the central nervous system (CNS) damage induced by METH is well documented, the role of peripheral immune ...
Rongji Hui, Jiabao Xu, Hongchen Ma, Tao Feng, Congcong Hou, Xintao Wang, Mingyang Jin, Feng Yu, Yan Shi, Bing Xie, Ludi Zhang, Bin Cong, Chunling Ma, Di Wen   +13 more
doaj   +1 more source

New markers for old stains: Stable mRNA markers for blood and saliva identification from up to 16-year-old stains [PDF]

, 2009
In forensic science, the unequivocal identification of the cellular origin of crime scene samples used for DNA profiling can provide crucial information for crime scene reconstruction.
Kokshoorn, M., Zubakov, D., Kokshoorn, M (Mieke), Kayser, M., Kloosterman, A., Kloosterman, AD, Kayser, Manfred, Zubakov, Dmitry   +7 more
core   +2 more sources

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

PRISM, a Bidirectional NMR Foundation Model: From Peak List to Structure and Back

Angewandte Chemie, EarlyView.
Structure elucidation from NMR can consume an expert for hours or even days. PRISM addresses this with a bidirectional transformer trained on 1.19 M real experimental spectra: it translates 1H and 13C peak lists into structures with 60.1% stereo‐aware top‐1 accuracy (72.5% stereo‐unaware), and, working in reverse, predicts spectra back from structures,
Ajnabiul Hoque, Frank Glorius
wiley   +2 more sources

Comprehensive Understanding the Forensic Systematic Effectiveness in Chinese Yunnan Hani Group and Intercontinental Population Architecture Differentiation Analyses via a Novel Set of Autosomal InDel Markers

Frontiers in Bioscience-Landmark, 2023
Background: Chinese Yunnan Hani group is an East Asian ethnic group mainly distributed in China, Thailand, Laos, Vietnam, and Burma. The genetic makeup of Chinese Yunnan Hani ethnic group remains to be further investigated. The insertion/deletion (InDel)
Hui Xu, Shengjie Nie, Liping Hu, Xuebing Chen, Ming Zhao, Xi Yuan, Yifeng Lin, Bofeng Zhu   +7 more
doaj   +1 more source

Coherent Analysis of Forensic Identification Evidence

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1996
SUMMARY A murder has been committed and there is a known population of possible suspects. The identification evidence available, based on information at the scene of the crime, is that the criminal may have a certain characteristic. Information may also be available on a set of suspects about which of them have the characteristic.
DAWID A. P, MORTERA, Julia
openaire   +3 more sources

Forensic science & human migration: The role of forensic genetics [PDF]

, 2019
Many migrants perish on dangerous journeys in search of a better life around the world. However, little is being done to identify these individuals. Forensic science has successfully been used to identify individuals following mass-casualty incidents ...
Brawn, R. J., McKie, Ruth E., Crisp, Annette, Johnston, Emma   +3 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source