Results 41 to 50 of about 36,449 (264)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice

Journal of Neuroinflammation
Methamphetamine (METH) abuse, a global public health concern, is closely linked to neuropsychiatric disorders such as depression. Although the central nervous system (CNS) damage induced by METH is well documented, the role of peripheral immune ...
Rongji Hui, Jiabao Xu, Hongchen Ma, Tao Feng, Congcong Hou, Xintao Wang, Mingyang Jin, Feng Yu, Yan Shi, Bing Xie, Ludi Zhang, Bin Cong, Chunling Ma, Di Wen   +13 more
doaj   +1 more source

Forensic Characteristics and Genetic Background Dissections of Chinese Manchu and Zhuang Groups Using 59 Autosomal Diallelic InDels and 2 miniSTRs

Frontiers in Bioscience-Landmark, 2022
Background: The latest development in molecular biology has offered an opportunity to construct multiplex panel with better applicability for forensic purpose, and a self-developed 64-plex panel, including 59 autosomal diallelic InDels, 2 miniSTRs, 2 Y ...
Fanzhang Lei, Meiming Cai, Shengjie Nie, Hui Xu, Qiong Lan, Xiaole Bai, Bofeng Zhu   +6 more
doaj   +1 more source

Coherent Analysis of Forensic Identification Evidence

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1996
SUMMARY A murder has been committed and there is a known population of possible suspects. The identification evidence available, based on information at the scene of the crime, is that the criminal may have a certain characteristic. Information may also be available on a set of suspects about which of them have the characteristic.
DAWID A. P, MORTERA, Julia
openaire   +3 more sources

Ameloglyphics: A Forensic Tool for Human Identification

Journal of Pharmacy and Bioallied Sciences, 2023
ABSTRACT Crime rates in our contemporary technological age have been rising at an alarming pace. Newer methods are needed to determine who the perpetrator and victim are in these situations. By comparing a person’s recorded information with their own unique characteristics, automated biometric systems may determine ...
openaire   +3 more sources

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel

Hereditas
Background The use of compound markers has gained significant interest among forensic practitioners, due to their ability to enhance genetic marker polymorphisms by introducing new alleles.
Qinglin Liang, Qiong Lan, Qinglin Liu, Xiaolian Wu, Lisiteng Luo, Chunmei Shen, Bofeng Zhu   +6 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Research Progress and Forensic Application of Postmortem Genetic Testing in Hereditary Cardiac Diseases

Fayixue Zazhi, 2022
Hereditary cardiac disease accounts for a large proportion of sudden cardiac death （SCD） in young adults. Hereditary cardiac disease can be divided into hereditary structural heart disease and channelopathies.
DONG Yi-ming, YANG Chen-teng, ZHANG Guo-zhong, CONG Bin   +3 more
doaj   +1 more source

Enhancing Biogenic Formic Acid Production in the Modified OxFA Process by Acetonitrile Addition

Advanced Science, EarlyView.
In this study, the beneficial effect of using acetonitrile as a co‐solvent in the modified OxFA process is shown, outperforming methanol, demonstrating improved reaction kinetics combined with high selectivity for the HPA‐2 (H5PV2Mo10O40) catalyzed oxidation of xylose to FA.
Jan‐Dominik H. Krueger, Pegah Saedi, Maximilian J. Poller, Alberto Collauto, Jason P. Hallett, David Robinson, Maxie M. Roessler, Jakob Albert   +7 more
wiley   +1 more source