Results 131 to 140 of about 15,036 (214)

Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach [PDF]

, 2015
© The Author(s) 2015. AIM: To investigate the possible involvement of Sirtuin 1 (SIRT1) in rat orthotopic liver transplantation (OLT), when Institute Georges Lopez 1 (IGL-1) preservation solution is enriched with trimetazidine (TMZ).
Abdennebi, Hassen B., Bejaoui, Mohamed, Folch-Puy, Emma, Palmeira, Carlos M., Pantazi, Eirini, Rolo, Anabela Pinto, Roselló-Catafau, Joan, Varela, Ana Teresa, Zaouali, Mohamed A.   +8 more
core   +2 more sources

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

Acta Pharmaceutica Sinica B
The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post injury. Label retaining cells (LRCs) expressing SRY-box transcription factor 9 (SOX9) promote epithelial repair by ...
Weilian Bao, Jiaren Lyu, Guize Feng, Linfeng Guo, Dian Zhao, Keyuan You, Yang Liu, Haidong Li, Peng Du, Daofeng Chen, Xiaoyan Shen   +10 more
doaj   +1 more source

RNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1

Nature Communications
Autoreactive CD4+ T helper cells are critical players that orchestrate the immune response both in multiple sclerosis (MS) and in other neuroinflammatory autoimmune diseases.
Xiaofan Yang, Xiaotong Zhu, Junli Sheng, Yuling Fu, Dingnai Nie, Xiaolong You, Yitian Chen, Xiaodan Yang, Qiao Ling, Huili Zhang, Xiaomin Li, Shengfeng Hu   +11 more
doaj   +1 more source

The role of appoptosin in regulating oxidative stress and mitochondrial morphology [PDF]

, 2015
氧化压力是指细胞或体内氧自由基的含量超出抗氧化物及抗氧化酶类清除能力时对细胞或机体造成的氧化胁迫。氧化压力参与了包括炎症、衰老、心血管疾病、癌症、糖尿病、艾滋病、神经退行性疾病等多种疾病的发病过程。氧化压力通过多个下游信号通路对细胞造成胁迫，如JNK、Foxo等，但其中的具体参与蛋白仍有待于深入阐明。Appoptosin也被称为SLC25A38，是一种定位于线粒体内膜的转运蛋白，负责转入甘氨酸并转出D-氨基乙酰丙酸，进而调节血红素（heme）的合成 ...
张翠林
core  

Exosomal miR-212-5p promotes tendon repair via targeting FOXO1 to activate PP1A/YAP1 signaling

Communications Biology
Tendon injury, resulting from repetitive strain or acute trauma, often leads to pain, reduced mobility, and impaired healing due to the limited regenerative capacity of tendon tissue.
Kefeng Lin, Xu Hu, Jin Yan, Renzhi Gao, Shishui Lin, Shiguo Zhou   +5 more
doaj   +1 more source

Forkhead box O1 mediates defects in palmitate-induced insulin granule exocytosis by downregulation of calcium/calmodulin-dependent serine protein kinase expression in INS-1 cells [PDF]

, 2015
Yao Wang, Haiyan Lin, Nana Hao, Zhengqiu Zhu, Dong Wang, Yuan Li, Hong Chen, Yunxia Zhu, Xiao Han   +8 more
openalex   +1 more source

MP88-08 ESTROGEN RECEPTOR (ER)-β SIGNALS INDUCE UROTHELIAL TUMORIGENESIS VIA DOWN-REGULATION OF A POTENTIAL TUMOR SUPPRESSOR FORKHEAD BOX PROTEIN O1 (FOXO1) [PDF]

, 2017
Hiroki Ide, Satoshi Inoue, Kazutoshi Fujita, Yi Li, Takashi Kawahara, Eiji Kashiwagi, Taichi Mizushima, Seiji Yamaguchi, Hiroaki Fushimi, Mototsugu Oya, Norio Nonomura, Hiroshi Miyamoto   +11 more
openalex   +1 more source

Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion

Cell Reports
Summary: Resolving the molecular mechanisms of central B cell tolerance might unveil strategies that prevent autoimmunity. Here, using a mouse model of central B cell tolerance in which Forkhead box protein O1 (Foxo1) is either deleted or over-expressed ...
Megan R. McCaleb, Anjelica M. Miranda, Hadeel A. Khammash, Raul M. Torres, Roberta Pelanda   +4 more
doaj   +1 more source

Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis

Cell Reports
Summary: Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary, causing infertility and chronic pain. However, its pathophysiology remains unclear.
Jia Yan, Ling Zhou, Mengya Liu, Honglan Zhu, Xin Zhang, E. Cai, Xueqiang Xu, Tinghan Chen, Hongyan Cheng, Jun’e Liu, Shang Wang, Lin Dai, Xiaohong Chang, Fuchou Tang   +13 more
doaj   +1 more source

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

Nature Communications
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation.
Xiaomei Zhang, Lihao Ge, Guanghui Jin, Yasong Liu, Qingfen Yu, Weizhao Chen, Liang Chen, Tao Dong, Kiyoharu J. Miyagishima, Juan Shen, Jinghong Yang, Guo Lv, Yan Xu, Qing Yang, Linsen Ye, Shuhong Yi, Hua Li, Qi Zhang, Guihua Chen, Wei Liu, Yang Yang, Wei Li, Jingxing Ou   +22 more
doaj   +1 more source