Results 111 to 120 of about 15,036 (214)
Neoplasia: An International Journal for Oncology Research, 2009 Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang +11 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Animals, 2020 This study investigated the effect of fermented diet on growth performance, carcass traits, meat quality and growth of longissimus thoracis (LT) of finishing pigs.
Yueqin Qiu +6 more
doaj +1 more source
Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]
, 2018 Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C. +6 more
core +1 more source
Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells [PDF]
, 2017 Endometrial decidualization represents an essential step for the successful implantation of the embryo; however, the molecular mechanism behind this differentiation process remains unclear.
Brosens, Jan J. +8 more
core +1 more source
Homeostatic maintenance of T cells and natural killer cells [PDF]
, 2018 Homeostasis in the immune system encompasses the mechanisms governing maintenance of a functional and diverse pool of lymphocytes, thus guaranteeing immunity to pathogens while remaining self-tolerant.
Boyman, Onur +3 more
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Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 [PDF]
, 2014 Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype by increasing expression of IL-23 ...
Kishi, Yasuhiro +7 more
core +1 more source
FOXO1 suppresses PGC‐1β gene expression in skeletal muscles
FEBS Open Bio, 2020 Peroxisome proliferator‐activated receptor‐gamma coactivator‐1β (PGC‐1β) is a transcriptional regulator whose increased expression activates energy expenditure‐related genes in skeletal muscles.
Shiho Nakai +6 more
doaj +1 more source
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 [PDF]
, 2014 The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) that control Skp2 activities ...
Inuzuka, Hiroyuki +6 more
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