Results 91 to 100 of about 15,036 (214)

AS1842856 Reduces β‐Amyloid Burden via Inhibiting PLA2G4A‐Mediated Lysosomal Dysfunction in APP/PS1 Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
AS1842856 reduces intracellular levels of GSK3α/β by binding to them and promoting their exocytosis. This reduction leads to diminished GSK3β‐mediated activation of NF‐κB, resulting in decreased transcription of PLA2G4A and reduced lysosomal damage. Ultimately, this enhances lysosomal degradation of Aβ, lowering Aβ load in APP/PS1 mice.
Da‐Long He, Zheng Wu, Rong‐Jun Jia, Ting‐Yao Wu, Yi‐Min Qiu, Yong‐Gang Fan   +5 more
wiley   +1 more source

Resveratrol improves contractile dysfunction, cell viability and oxidative stress in adult rat cardiomyocytes exposed to norepinephrine via SOD/FOXO1

Journal of Functional Foods
In heart failure, cardiac remodeling and dysfunction are driven by abnormalities of cardiomyocyte caused by excessive circulating norepinephrine (NE). This study examined resveratrol's effect on NE-exposed adult rat cardiomyocytes.
Pema Raj, Liping Yu, Huong Nguyen, Inna Rabinovich-Nikitin, Sijo Joseph Thandapilly, Jeffrey Wigle, Shelley Zieroth, Thomas Netticadan   +7 more
doaj   +1 more source

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]

, 2008
The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert, Henderson, Colin, Scott, Claire, Wolf, Roland   +3 more
core   +2 more sources

Effects of Diet Strategy and Nutrients on the Progression and Prevention of Diabetic Cardiomyopathy: A Narrative Review

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Dietary strategies modulate the progression of diabetic cardiomyopathy by targeting oxidative stress, inflammation, mitochondrial dysfunction, and myocardial fibrosis. Specific nutrients and bioactive compounds, as well as caloric restriction, improve myocardial metabolism and redox balance, whereas ketogenic diets exert time‐dependent beneficial or ...
Wen‐hui Deng, Kai‐xuan Lin, Abdallah Iddy Chaurembo, Francis Chanda, Yuan Li, Li‐Dan Fu, Hao‐Dong Cui, Xin‐Yue Tong, Chi Shu, Han‐Bin Lin   +9 more
wiley   +1 more source

Cellular angiofibroma in women: A review of the literature [PDF]

, 2015
Cellular Angiofibroma (CA) represents a quite recently described mesenchymal tumour that occurs in both genders, in particular in the vulvo-vaginal region in women and in the inguino-scrotal area in men.
Abrate, Martino, Aguzzoli, Lorenzo, Cavazza, Alberto, LA SALA, Giovanni Battista, Mandato, Vincenzo Dario, SANTAGNI, SUSANNA   +5 more
core   +1 more source

Maternal Obesity Programs Adipogenic Commitment in Neonatal Mesenchymal Stem Cells: A Link to Redox‐Dependent FOXO1 Signaling

Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.
ABSTRACT Maternal obesity increases the risk of obesity and metabolic disease in the offspring, yet the cellular mechanisms that program adipose tissue development remain poorly understood. Mesenchymal stem cells (MSCs), the precursors of adipocytes, may represent an early target of metabolic programming during fetal development.
Sofía Bellalta, Erika Pinheiro‐Machado, Theo Borghuis, Jelmer Prins, Torsten Plösch, Paola Casanello, Marijke Faas   +6 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction [PDF]

, 2017
During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-Term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI.
Ambagtsheer, G., Bruin, R.W.F. (Ron) de, Dollé, M. (MartijnE.T.), Engel, S. (Sandra) van den, Hoeijmakers, J.H.J. (Jan), Ijzermans, J.N.M., Imholz, S. (Sandra), Jongbloed, F. (Franny), Oostrom, C.T.M. (Conny) van, Payan-Gomez, C., Pennings, J.L.A. (Jeroen L.A.), Saat, T.C. (Tanja), Steeg, H. (Harry) van, Verweij, M. (Marcel)   +13 more
core   +2 more sources

The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta‐Analysis

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
SGLT2 inhibitors reduce skeletal muscle mass modestly in older adults with type 2 diabetes. Forest plot (a) and count our funnel plot (b) show a small but significant pooled reduction in muscle mass (SMD = −0.36, 95% CI [−0.56, −0.15]; I2 = 24.1%), with weight loss occurring predominantly through fat mass reduction.
Weena Joongpan, Nittaya Boonmuen, Pimthong Sinchai, Sarawut Lapmanee, Natawat Klamsakul, Nutthapoom Pathomthongtaweechai   +5 more
wiley   +1 more source

Effects of AMPK/PGC-1α on gluconeogenesis in skeletal muscle of animals under overwintering starvation and its molecular mechanism: review [PDF]

Animal Bioscience
During the wintering period characterized by feed scarcity, animals activate the sympathetic nervous system (SNS)-β-adrenergic receptor (βAR)-AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)
Chaoyong Huang, Huiyu Cheng, Binhong Wen, Wei Li, Baohua Luo, Dubala Wu, Jingshun Wang, Sile Hu, Jianghong Wu   +8 more
doaj   +1 more source