Results 81 to 90 of about 15,036 (214)

Developing a mouse model to study the metabolic role of the mammalian target of rapamycin complex 1 in adipose tissue [PDF]

, 2016
The term "diabesity" is a pandemic that is threatening populations worldwide and is the term is finding itself as a household name, fueling itself through the high-fat diet and sedentary lifestyle.
Thimmiah, Harun
core   +1 more source

Potential Effects of Prepubertal Exposure to Perfluorooctane Sulfonic Acid on the First Wave of Folliculogenesis in Young CD‐1 Mice

Birth Defects Research, Volume 118, Issue 5, May 2026.
ABSTRACT Background Perfluorooctane sulfonic acid (PFOS) belongs to a group of synthetic chemicals referred to as per‐ and polyfluoroalkyl substances (PFAS) that are known to degrade slowly. Exposure to PFOS has been reported to cause birth defects and disrupt female sex hormone levels in mice.
Bounleut Phanavanh, Jalina Moore, Amy Inselman, Xiaoqing Li, Kyung Sung, Pei‐Hsuan Hung, Li You, Noriko Nakamura   +7 more
wiley   +1 more source

Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction

Archives of Medical Science
Introduction Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised.
Katarina Banjac, MIlan Obradovic, Sonja Zafirovic, Esma R. Isenovic   +3 more
doaj   +1 more source

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

iScience, 2023
Summary: Atherosclerosis complicates chronic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus, suggesting that a shared physiological pathway regulates inflammatory responses in these diseases wherein spleen tyrosine ...
Daisuke Tsukui, Yoshitaka Kimura, Hajime Kono   +2 more
doaj   +1 more source

Angiotensin-(1-7): Beyond the Cardio-Renal Actions [PDF]

, 2012
It is well known that the RAS (renin–angiotensin system) plays a key role in the modulation of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) has a central role in mediating most of the actions of the RAS ...
Passos-Silva, Danielle G, Santos, Robson AS, Verano-Braga, Thiago   +2 more
core   +1 more source

Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Kidney size is sex‐dimorphic and regulated by androgens in adult humans and mice. Male mice lacking the main testosterone‐producing enzyme HSD17B3 had reduced testosterone during a short fetal time window, leading to reduced size of kidneys in adults, which were not responsive to high adult testosterone.
Arttu Junnila, Kalle T. Rytkönen, Guillermo Martinez‐Nieto, Mats Perk, Otto Mäkelä, Hao Li, Jenni Airaksinen, Ida Hyötyläinen, Oliver Mehtovuori, Asta Laiho, Claes Ohlsson, Laura L. Elo, Satu Kuure, Matti Poutanen, Petra Sipilä   +14 more
wiley   +1 more source

Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes [PDF]

, 2021
Rongxue Wei, Chunchun Han, Fengjiang Ye, Shouhai Wei, Fang He, Hehe Liu, Liang Li, Hongyong Xu, Shenqiang Hu, Xianyin Zeng   +9 more
openalex   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension [PDF]

, 2017
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death ...
Lawrie, A., Thompson, A.A.R.
core   +1 more source