Results 101 to 110 of about 15,036 (214)
Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.In GERD, elevated PAR2 expression impaired esophageal mucosal barrier function by downregulating and inducing the redistribution of Claudin‐1 and Claudin‐4, while promoting M1 macrophage‐mediated secretion of IL‐8 and IL‐1β. ABSTRACT Background Gastric content reflux activates protease‐activated receptor 2 (PAR2), which is a critical step in the ...
Mengdie Du +5 more
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Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches [PDF]
, 2017 Diabetic microangiopathy, including retinopathy, is characterized by abnormal growth and leakage of small blood vessels, resulting in local edema and functional impairment of the depending tissues. Mechanisms leading to the impairment of microcirculation
Balistreri, C.R. +3 more
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XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells
Scientific Reports, 2017 The purpose of this study was to clarify the relationship among X-box-binding protein 1 unspliced, spliced (XBP1u, s), Forkhead box O1 (FoxO1) and autophagy in the auditory cells under endoplasmic reticulum (ER) stress.
Akihiro Kishino +5 more
doaj +1 more source
Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition [PDF]
, 2017 Background: The decidua has been implicated in the "terminal pathway" of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues.
Balogh, A. +5 more
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Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation
Gut Medicine, Volume 2, Issue 1, Page 23-39, March 2026.ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei +5 more
wiley +1 more source
FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer’s disease
Clinical Interventions in Aging, 2014 Giulia Paroni,1 Davide Seripa,1 Andrea Fontana,2 Grazia D’Onofrio,1 Carolina Gravina,1 Maria Urbano,1 Leandro Cascavilla,2 Fabio Pellegrini,2,3 Antonio Greco,1 Alberto Pilotto1,4 1Gerontology and Geriatrics Research Laboratory, 2Unit of ...
Paroni G +9 more
doaj
Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]
, 2017 Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core
Estrogen Receptor Transrepresses Brain Inflammation [PDF]
, 2011 Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al.
Gosselin, David, Rivest, Serge
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Gut Medicine, Volume 2, Issue 1, Page 40-57, March 2026.ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley +1 more source
iMetaOmics, Volume 3, Issue 1, March 2026.Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley +1 more source