Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains [PDF]
, 2018 Objectives: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function.
Ardura, J. A. +7 more
core +2 more sources
LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205
Tumor Biology, 2017 Growth arrest special 5 (GAS5) is a long non-coding RNA reported to function as an inhibitor in various tumors including cervical cancer. However, the molecular mechanism of GAS5 involved in cervical cancer progression remains far from being elucidated ...
Wenwu Yang +5 more
doaj +1 more source
Progesterone-dependent induction of phospholipase C-related catalytically inactive protein 1 (PRIP-1) in decidualizing human endometrial stromal cells [PDF]
, 2016 Decidualization denotes the transformation of endometrial stromal cells into specialized decidual cells. In pregnancy, decidual cells form a protective matrix around the implanting embryo, enabling coordinated trophoblast invasion and formation of a ...
Blanks, Andrew M. +7 more
core +2 more sources
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding [PDF]
, 2016 published_or_final_versio
Birnbaum, MJ +11 more
core +2 more sources
Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation
Molecules, 2020 In the present study, we isolated a lignan ((−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS) from Alnus japonica and evaluated its antiobesity potential in vitro. We also determined its mechanism of action in a mouse pre-adipocyte 3T3-L1 cell line.
Hyejin Lee, Ji Hye Jeong, Jae-Ha Ryu
doaj +1 more source
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes [PDF]
, 2020 BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders.
Davidson, Nicholas O +2 more
core +1 more source
, 2008 This report contains a gene expression summary of the dentate gyrus (DG), derived from the Allen Brain Atlas (ABA) _in situ_ hybridization mouse data set.
Allen Institute for Brain Science +3 more
core +2 more sources
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
core +1 more source
CARM1 Regulates AMPK Signaling in Skeletal Muscle
iScience, 2020 Summary: Coactivator-associated arginine methyltransferase 1 (CARM1) is an emerging mediator of skeletal muscle plasticity. We employed genetic, physiologic, and pharmacologic approaches to determine whether CARM1 regulates the master neuromuscular ...
Derek W. Stouth +6 more
doaj +1 more source
The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]
, 2017 Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D +12 more
core +3 more sources