Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]
, 2017 The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian +11 more
core +1 more source
Aerobic Exercise Ameliorates Adverse Vascular Remodeling in Diabetes via PDK1/FoxO1 Axis. [PDF]
FASEB JReduced PDK1 expression in the carotid arteries of type 1 diabetic mice promotes abnormal FoxO1 expression, thereby inducing inflammatory responses and vascular remodeling. These phenotypes can be ameliorated by regular aerobic exercise. In vitro experiments further confirm that the PDK1‐FoxO1 signaling axis in a high‐glucose environment can induce ...
Xie X, Zhang Z, Yang X, Chu M.
europepmc +2 more sources
Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice [PDF]
Endocrinology and Metabolism, 2021 Background Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have not yet been examined.
Dae Hyun Kim +9 more
doaj +1 more source
Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]
, 2016 Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent +5 more
core +1 more source
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]
, 2017 Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello +3 more
core +1 more source
Scientific Reports, 2021 Nitric oxide (NO) is produced from endothelial cells and cardiomyocytes composing the myocardium and benefits cardiac function through both vascular-dependent and—independent effects.
Pu Wang +10 more
doaj +1 more source
Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]
, 2015 Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara +6 more
core +1 more source
Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]
, 2017 Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core +1 more source
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation. [PDF]
, 2017 Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1).
Ding, Lijun +10 more
core +2 more sources