Results 41 to 50 of about 15,036 (214)

Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice. [PDF]

PLoS ONE, 2014
Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced ...
Lan Zhang, Shu Meng, Qisheng Tu, Liming Yu, Yin Tang, Michel M Dard, Sung-Hoon Kim, Paloma Valverde, Xuedong Zhou, Jake Chen   +9 more
doaj   +1 more source

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics

Cancer Cell International, 2023
Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas ...
Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad, Mahdieh Soleimani   +3 more
doaj   +1 more source

Atractylenolide III alleviates sepsis-mediated lung injury via inhibition of FoxO1 and VNN1 protein

Acta Cirúrgica Brasileira, 2021
Purpose: To evaluate the influence of atractylenolide (Atr) III on sepsis-induced lung damage. Methods: We constructed a mouse sepsis model through cecal ligation and puncture. These mice were allocated to the normal, sepsis, sepsis + Atr III-L (2 mg/kg)
Ji-ding Fu, Chun-hui Gao, Shi-wei Li, Yan Tian, Shi-cheng Li, Yi-er Wei, Le-wu Xian   +6 more
doaj   +1 more source

Role of Forkhead box protein O1 (FOXO-1) and Clinical Laboratory Investigations Assist to Investigate the Severity of COVID-19 [PDF]

International Journal of Applied Biochemistry and Molecular Biology
Mohamed Elsayed, Hatem A. El‐mezayen, Olfat Shaker, Yasmine Abdelfatah, Sara M. Abdo   +4 more
openalex   +2 more sources

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +1 more source

Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway

Redox Biology, 2021
Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy and deactivates apoptotic cell death through the Forkhead box ...
Ilenia Martinelli, Andrei Timotin, Paula Moreno-Corchado, Dimitri Marsal, Solomiia Kramar, Halina Loy, Carine Joffre, Frederic Boal, Helene Tronchere, Oksana Kunduzova   +9 more
doaj   +1 more source

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Nature Communications, 2021
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF.
Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine, Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill   +20 more
doaj   +1 more source

Dual regulation of TxNIP by ChREBP and FoxO1 in liver

iScience, 2021
Summary: TxNIP (Thioredoxin-interacting protein) is considered as a potential drug target for type 2 diabetes. Although TxNIP expression is correlated with hyperglycemia and glucotoxicity in pancreatic β cells, its regulation in liver cells has been less
Benedicte Noblet, Fadila Benhamed, InSug O-Sullivan, Wenwei Zhang, Gaëlle Filhoulaud, Alexandra Montagner, Arnaud Polizzi, Solenne Marmier, Anne-Françoise Burnol, Sandra Guilmeau, Tarik Issad, Hervé Guillou, Catherine Bernard, Terry Unterman, Catherine Postic   +14 more
doaj   +1 more source

Thioredoxin mitigates H2O2‐induced inhibition of myogenic differentiation of rat bone marrow mesenchymal stem cells by enhancing AKT activation

FEBS Open Bio, 2020
Thioredoxin (Trx) is a hydrogen acceptor of ribonucleotide reductase and a regulator of some enzymes and receptors. It has been previously shown that significantly elevated levels of Trx expression are associated with the osteogenic differentiation of ...
Meiling Liu, Xianglu Li, Changlin Zhou, Manfeng Wang, Hongzhi Wang, Haifeng Ding, Luyang Cheng, Lu Gan, Xiaowei Wu, Zhimin Du   +9 more
doaj   +1 more source

CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas

Haematologica, 2020
B-cell receptor (BCR) signaling pathway components represent promising treatment targets in multiple B-cell malignancies including diffuse large B-cell lymphoma (DLBCL).
Linfeng Chen, Jing Ouyang, Kirsty Wienand, Kamil Bojarczuk, Yansheng Hao, Bjoern Chapuy, Donna Neuberg, Przemyslaw Juszczynski, Lee N. Lawton, Scott J. Rodig, Stefano Monti, Margaret A. Shipp   +11 more
doaj   +1 more source