Results 21 to 30 of about 15,036 (214)
Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin [PDF]
Journal of Lipid Research, 2014 Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Taiyi Kuo +6 more
doaj +3 more sources
Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein [PDF]
Journal of Biological Chemistry, 2015 Diabetes is accompanied by dysregulation of glucose, lipid, and protein metabolism. In recent years, much effort has been spent on understanding how insulin regulates glucose and lipid metabolism, whereas the effect of insulin on protein metabolism has received less attention.
Qing Chen +3 more
openalex +4 more sources
Archives of Oral Biology, 2016 Porphyromonas gingivalis (P. gingivalis) is a pathogen involved in periodontal disease. Recently, periodontal disease has been demonstrated to increase the risk of developing diabetes mellitus, although the molecular mechanism is not fully understood.
Haruna Takamura +4 more
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Leucine promotes differentiation of porcine myoblasts through the protein kinase B (Akt)/Forkhead box O1 signalling pathway [PDF]
British Journal of Nutrition, 2018 AbstractLeucine, one of the branched-chain amino acids, is the only amino acid to regulate protein turnover in skeletal muscle. Leucine not only increases muscle protein synthesis, but also decreases muscle protein degradation. It is well documented that leucine plays a positive role in differentiation of murine muscle cells.
Shurun Zhang +9 more
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Journal of Microbial & Biochemical Technology, 2017 Probiotics are widely used to promote health benefits around the world. Nevertheless, the mechanisms whereby probiotics exert its beneficial effect on the host are not well elucidated yet. In an attempt to obtain relevant insights on probiotics mechanisms of action, we studied the probiotic response via Nuclear factor-κB (NF-κB) and Forkhead box ...
Ana Paula Mulet +4 more
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Journal of Global Oncology, 2019 61 Background: Transcriptional factor, Forkhead box protein O1 (FOXO1) has been reported to play an imported role in human cancer, but the role in epithelial ovarian cancer (EOC) has not yet been clarified. Here, we evaluatedthe expression and clinical significance of FOXO1 in EOC.
Hanbyoul Cho +2 more
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Genetics and Molecular Research, 2015 Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer.
B. Zhang +5 more
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Forkhead Box Protein O1 (FoxO1) Regulates Aortic Valve Interstitial Cell Calcification
SSRN Electronic Journal, 2022 Aileen Zhong +3 more
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Evaluation of nephroblastoma overexpressed gene, a transcriptional target of forkhead box protein O1 in type 2 diabetes mellitus [PDF]
QJM: An International Journal of Medicine, 2018 Abstract Background Type 2 diabetes mellitus (DM) is a chronic metabolic disease. The aim of this study was to evaluate the expression of FOXO1 and its target CCN3 in patients with type 2 DM in a trial to explore the molecular mechanism underlying β cell failure and to correlate the relationship between the two gene expressions, to each other, to ...
H. Said +3 more
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Forkhead Box Protein O1 Negatively Regulates Skeletal Myocyte Differentiation through Degradation of Mammalian Target of Rapamycin Pathway Components [PDF]
Endocrinology, 2007 The forkhead transcription factor forkhead box protein O1 (FoxO1), a downstream target of phosphatidylinositol 3-kinase/Akt signaling, has been reported to suppress skeletal myocyte differentiation, but the mechanism by which FoxO1 regulates myogenesis is not fully understood.
Ai-Luen Wu +4 more
openalex +3 more sources