Results 11 to 20 of about 15,036 (214)

Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer. [PDF]

Int J Clin Oncol, 2019
Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) have been reported to play an imported role in human cancers, but their role in cervical cancer has not yet been clarified. In this study, we evaluated the functional role of FOXO1 in cervical cancer cells and investigated the expression and clinical significance of FOXO1 and PAX3 in cervical
Chay DB, Han GH, Nam S, Cho H, Chung JY, Hewitt SM.   +5 more
europepmc   +7 more sources

Upregulation of microRNA-370 facilitates the repair of amputated fingers through targeting forkhead box protein O1. [PDF]

Exp Biol Med (Maywood), 2016
Angiogenesis is critical to the success of digital replantation. Recent study suggests an important regulatory role of microRNA-370 (miR-370) in ischemia–reperfusion injury. However, its function in digital replantation is poorly understood. In this study, we reported that the expression of miR-370 was upregulated in replantation tissues.
Zhang H, Sun X, Hao D.
europepmc   +6 more sources

Sirtuin 1 Inhibits Fatty Acid Synthesis through Forkhead Box Protein O1-Mediated Adipose Triglyceride Lipase Expression in Goat Mammary Epithelial Cells. [PDF]

Int J Mol Sci
Sirtuin 1 (SIRT1) is a key upstream regulator of lipid metabolism; however, the molecular mechanisms by which SIRT1 regulates milk fat synthesis in dairy goats remain unclear. This study aimed to investigate the regulatory roles of SIRT1 in modulating lipid metabolism in goat mammary epithelial cells (GMECs) and its impact on the adipose triglyceride ...
He Q, Yao W, Lv L, Zhang X, Wu J, Luo J.
europepmc   +5 more sources

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion. [PDF]

J Biol Chem, 2019
FoxO proteins are major targets of insulin action, and FoxO1 mediates the effects of insulin on hepatic glucose metabolism. We reported previously that serpinB1 is a liver-secreted factor (hepatokine) that promotes adaptive β-cell proliferation in response to insulin resistance in the liver-specific insulin receptor knockout (LIRKO) mouse.
El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG.   +11 more
europepmc   +6 more sources

Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1. [PDF]

Int J Med Sci
Background: Nasopharyngeal carcinoma (NPC) is an epithelial tumor of the head and neck with heterogeneous racial and geographical distributions. Homeobox B2 (HOXB2) is a tumor promoter in many cancers. However, the biological role of HOXB2 in NPC has not been elucidated.
Chen J, Mao M, Ma Z, Liu J, Jiang M, Chen G, Xu Y.   +6 more
europepmc   +5 more sources

β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition. [PDF]

World J Diabetes
In this editorial, we highlight the study by Wang et al published in a recent issue of the World Journal of Diabetes . Type 2 diabetes is increasingly recognized as a β-cell dysfunction disorder, with apoptosis and dedifferentiation being key factors in insulin secretion loss.
Al Madhoun A, Bahman F, Ahmad R.
europepmc   +4 more sources

Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group. [PDF]

Cancer, 2018
BACKGROUNDPediatric paired box 3:forkhead box protein O1 fusion–negative (PF–) rhabdomyosarcoma (RMS) represents a diverse spectrum of tumors with marked differences in histology, myogenic differentiation, and clinical behavior.METHODSThis study sought to evaluate the clinical and mutational spectrum of 24 pediatric PF– human RMS tumors with high ...
Teot LA, Schneider M, Thorner AR, Tian J, Chi YY, Ducar M, Lin L, Wlodarski M, Grier HE, Fletcher CDM, van Hummelen P, Skapek SX, Hawkins DS, Wagers AJ, Rodriguez-Galindo C, Hettmer S.   +15 more
europepmc   +5 more sources

Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation. [PDF]

World J Diabetes
BACKGROUND Type 2 diabetes mellitus is characterized by pancreatic β-cell dysfunction and insulin resistance. Studies have suggested that β-cell dedifferentiation is one of the pathogeneses of β-cell dysfunction, but the detailed mechanism is still unclear.
Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY, Wang W.   +7 more
europepmc   +3 more sources

Role of forkhead box protein O1 and insulin on cell proliferation mediated by sirtuin 1 in goose primary hepatocytes

Journal of Applied Poultry Research, 2021
Summary: To explore the role of insulin and forkhead box protein O1 (FoxO1) on cell proliferation regulated by sirtuin 1 (Sirt1) in goose primary hepatocyte, goose primary hepatocytes were isolated and incubated with Sirt1 inhibitor and nicotinamide, and
Rongxue Wei, Chunchun Han, Fang He, Xiangping Xiong, Fengjiang Ye, Hehe Liu, Liang Li, Hongyong Xu, Shouhai Wei, Xianyin Zeng   +9 more
doaj   +3 more sources

Forkhead Box O1 (FOXO1) Protein, but Not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice [PDF]

Journal of Biological Chemistry, 2013
Reporter mice that enable the activity of the endogenous p21 promoter to be dynamically monitored in real time in vivo and under a variety of experimental conditions revealed ubiquitous p21 expression in mouse organs including the brain. Low light bioluminescence microscopy was employed to localize p21 expression to specific regions of the brain ...
Kelsey L. Tinkum, Lynn S. White, Luciano Marpegán, Erik D. Herzog, David Piwnica‐Worms, Helen Piwnica‐Worms   +5 more
openalex   +5 more sources