The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells [PDF]
Nicolas Jonckheere+10 more
openalex +1 more source
ABSTRACT Acne vulgaris is a common inflammatory condition that is often treated by dermatologists with isotretinoin. Isotretinoin has a number of effects on inflammatory pathways, with clear efficacy in managing acne vulgaris. There are also well‐documented side effects of isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk
Timothy L. Cowan+3 more
wiley +1 more source
Conversion of a Replication Origin to a Silencer through a Pathway Shared by a Forkhead Transcription Factor and an S Phase Cyclin [PDF]
Laurieann Casey+3 more
openalex +1 more source
Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia
Abstract Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both organ development and homeostasis, primary cilia in the human male reproductive excurrent duct have been ...
Ludovic Vinay+2 more
wiley +1 more source
Natural products targeting tumour angiogenesis
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu+2 more
wiley +1 more source
Transcriptional Cross Talk between the Forkhead Transcription Factor Forkhead Box O1A and the Progesterone Receptor Coordinates Cell Cycle Regulation and Differentiation in Human Endometrial Stromal Cells [PDF]
Masashi Takano+14 more
openalex +1 more source
ABSTRACT Tropical wetlands are some of the most threatened ecosystems in the world. Pterocarpus officinalis exists in swampy wetlands in riparian and fresh‐water coastal areas across the neotropics, supporting biodiversity and storm surge and flooding protection as well as water filtration. In Puerto Rico, P.
Sean M. Collins+7 more
wiley +1 more source
FOXOs and their roles in acute and chronic neurological disorders. [PDF]
Asadi Y+4 more
europepmc +1 more source
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman+5 more
wiley +1 more source