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Forkhead transcription factors: key players in health and disease [PDF]
Trends in Genetics, 2011 Forkhead box (FOX) proteins constitute an evolutionarily conserved family of transcription factors with a central role not only during development, but also in the adult organism. Thus, the misregulation and/or mutation of FOX genes often induce human genetic diseases, promote cancer or deregulate ageing.
Sandrine Caburet +4 more
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Forkhead transcription factor Foxo1 is essential for adipocyte differentiation [PDF]
In Vitro Cellular & Developmental Biology - Animal, 2009 We analyzed the physiological role of forkhead box class O 1 (Foxo1) in adipocyte differentiation by suppressing Foxo1 mRNAwith siRNA specific for Foxo1.Mouse 3T3-L1 preadipocytes infected with an adenovirus expressing Foxo1-siRNA showed a marked decrease in lipid droplet formation when induced to differentiate into adipocytes.
Kazuichi Sakamoto, Keisuke Munekata
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Expression of forkhead transcription factors in human granulosa cells
Fertility and Sterility, 2009Members of the forkhead box O1 (FOXO) family of transcription factors are expressed in granulosa cells during various stages of follicle development, and evidence from rodent and other model systems suggests that they may be involved in regulating follicular activation and oocyte maturation.
Margareta D. Pisarska +5 more
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Forkhead family transcription factor FoxO and neural differentiation
neurogenetics, 2012The Forkhead Box subgroup O (FoxO) transcription factor family is one of the most important downstream targets of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway playing an important role in many biological functions including transcriptional regulation of cellular differentiation.
Peter J. Little +7 more
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Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2009AbstractForkhead transcription factor (Fox) e1 is a causative gene for Bamforth–Lazarus syndrome, which is characterized by hypothyroidism and cleft palate. Applying degenerate polymerase chain reaction using primers specific for the conserved forkhead domain, we identified zebrafish foxe1 (foxe1).
Sumiko Watanabe +3 more
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Ferroptosis, Iron Metabolism, and Forkhead Transcription Factors (FoxOs)
Current Neurovascular Research, 2023openaire +2 more sources
Forkhead-box transcription factors and their role in the immune system
Nature Reviews Immunology, 2004It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX
Boudewijn M.T. Burgering, Paul J. Coffer
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Pathophysiological Relevance of Forkhead Transcription Factors in Brain Ischemia
2009Forkhead box transcription factor, class 0 (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamiies of forkhead transcription factors such as FOXO1 (FKHR). FOXO3 (FKHRL1), FOXO4 (AFX) and FOXO6.
Norifumi Shioda, Kohji Fukunaga
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Forkhead transcription factors contribute to execution of the mitotic programme in mammals
Nature, 2001Cell cycle progression is a process that is tightly controlled by internal and external signals. Environmental cues, such as those provided by growth factors, activate early signals that promote cell cycle entry. Cells that have progressed past the restriction point become independent of growth factors, and cell cycle progression is then controlled ...
Boudewijn M.T. Burgering +3 more
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Roles of transposable elements in the regulation of mammalian transcription
Nature Reviews Molecular Cell Biology, 2022Julius Judd +2 more
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