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Forkhead box-O transcription factor: critical conductors of cancer's fate
Endocrine Related Cancer, 2008Cells have evolved elaborated mechanisms to coordinate the cellular answer of either survival or apoptosis. Recent concepts of human carcinogenesis have suggested disturbances in these cellular relays as a potential link to cellular dedifferentiation and uncontrolled proliferation.
Weidinger, Carl +4 more
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Pathophysiological Relevance of Forkhead Transcription Factors in Brain Ischemia
2009Forkhead box transcription factor, class 0 (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamiies of forkhead transcription factors such as FOXO1 (FKHR). FOXO3 (FKHRL1), FOXO4 (AFX) and FOXO6.
Kohji, Fukunaga, Norifumi, Shioda
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Forkhead Box O Transcription Factors: Key Players in Redox Signaling
Antioxidants & Redox Signaling, 2011The Forkhead Box O (FOXO) transcription factors are famous for their role in longevity: both Caenorhabditis elegans and Drosophila melanogaster can extend their median and maximum lifespan in a FOXO-dependent manner, and certain single nucleotide polymorphisms in human FOXO genes are associated with reaching an age above 100 years.
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Transcription Factors: Forkhead Box (FOX)
2022Vladimir V. Kalinichenko +2 more
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FOXO transcription factors as mediators of stress adaptation
Nature Reviews Molecular Cell Biology, 2023Tobias B Dansen, Boudewijn M T Burgering
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The role of transcription factors in shaping regulatory T cell identity
Nature Reviews Immunology, 2023Behdad Afzali, Majid Kazemian
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Forkhead transcription factors II.
Cell, 2008Geetu, Tuteja, Klaus H, Kaestner
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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
Nature, 2000René H Medema +2 more
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell, 1999Anne Brunet, Azad Bonni, Michael Z Lin
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