Results 101 to 110 of about 3,855,358 (269)

The interaction-driven starburst contribution to the cosmic star formation rate density

, 2013
An increasing amount of observational evidence supports the notion that there are two modes of star formation: a quiescent mode in disk-like galaxies, and a starburst mode, which is generally interpreted as driven by merging.
Fiore, Fabrizio, Lamastra, Alessandra, Menci, Nicola, Santini, Paola   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Créer dans l’urgence une formation à distance de qualité pour former... à la formation à distance : tout un défi!

Revue internationale des technologies en pédagogie universitaire, 2021
Cathia Papi, Caroline Brassard, Patrick Plante, Isabelle Savard, Gustavo Angulo Mendoza, Serge Gérin-Lajoie   +5 more
doaj   +1 more source

Knowledge Structures. [PDF]

This paper investigates how technological distance between firms affects their network of R&D alliances. Our theoretic model assumes that the benefit of an alliance between two firms is given by their technological distance.
Geert Duysters, Moritz Müller, Nicolas JONARD, Robin COWAN   +3 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Quelle appréciation de la formation à distance aujourd’hui ? Le point de vue de quelques enseignants en contexte postpandémique

Médiations & Médiatisations
La pandémie a été l’occasion, pour beaucoup d’enseignants, de découvrir ou d’approfondir leurs connaissances et compétences en formation à distance (FAD).
Cathia Papi
doaj   +1 more source

The Fine Line Between Normal and Starburst Galaxies

, 2017
Recent literature suggests that there are two modes through which galaxies grow their stellar mass - a normal mode characterized by quasi-steady star formation, and a highly efficient starburst mode possibly triggered by stochastic events such as galaxy ...
Casey, Caitlin M., Cortzen, Isabella, Damjanov, Ivana, Guijarro, Carlos Gomez, Karim, Alexander, Lee, Nicholas, Leslie, Sarah K., Magdis, Georgios, Schinnerer, Eva, Scott, Kimberly S., Sheth, Kartik, Toft, Sune, Zahid, H. Jabran   +12 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The star cluster mass--galactocentric radius relation: Implications for cluster formation

, 2015
Whether or not the initial star cluster mass function is established through a universal, galactocentric-distance-independent stochastic process, on the scales of individual galaxies, remains an unsolved problem.
Cameron, Ewan, de Grijs, Richard, Fan, Zhou, Sun, Weijia   +3 more
core   +1 more source