Results 81 to 90 of about 3,855,358 (269)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Star formation in a diffuse high-altitude cloud?

, 2016
A recent discovery of two stellar clusters associated with the diffuse high-latitude cloud HRK 81.4-77.8 has important implications for star formation in the Galactic halo.
Kerp, J., Lenz, D., Roehser, T.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Les logiciels libres

Revue Internationale d’Éducation de Sèvres, 1999
The « UNESCO-Netdays Project in Latin America and the Carribean » seeks to promote regional cooperative work through the use of free software and Internet in education. The Project gives a new basis for exchanges with European institutions.
Guillermo Lozano, Rodrigo Laurens
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Formation à distance sur la communication scientifique par affiche

Médiations & Médiatisations, 2019
La formation à distance constitue une pratique encore nouvelle pour plusieurs acteurs de l’enseignement universitaire. Des bibliothécaires universitaires éprouvent depuis quatre ans une formation à distance sur la communication scientifique par affiche ...
Catherine Seguin, Michel Courcelles
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Analyse d'une formation plurilingue à distance : actions et interactions

ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2006
This paper focuses on analysing three sessions of cross-comprehension training in romance languages which took place using similar scenarii on the e-learning platform "Galanet"."Galanet" learning schemes assemble large groups of students (from one to two
Jean-Jacques Quintin, Monica Masperi
doaj   +1 more source

L’autoévaluation en formation à distance [PDF]

, 2016
Comprend des références bibliographiquesQu’est-ce que l’autoévaluation? Quels sont ses buts? Quels peuvent être les objets de l’autoévaluation? Quand et comment planifier une autoévaluation?
Fontaine, Jonathan, Gauthier, Laurence, Leroux, Julie Lyne, Munn, Yves, Ringuet, Sophie   +4 more
core