Results 51 to 60 of about 397,381 (260)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
La formation continue numérisée face à ses discontinuités
Lien Social et Politiques, 2018 Dans un contexte caractérisé par la volonté d’accroître la responsabilisation individuelle des salariés dans l’acquisition et le maintien de leurs compétences professionnelles, l’utilisation du numérique apparaît aux yeux de certains décideurs comme une ...
Anca Boboc, Jean-Luc Metzger
doaj +1 more source
L’école à la recherche du temps perdu
Revue Internationale d’Éducation de Sèvres, 1997 Après la révolution des œillets (1974), le système éducatif portugais fait l’objet d’importantes réformes et/ou innovations. Les grands débats sont ceux de la formation permanente des enseignants, de l’autonomie des établissements scolaires en liaison ...
Rui Canário
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
دراسات العدد الاقتصادي, 2011 Cet article propose d’analyser les pratiques de gestion des ressources humaines mises en oeuvres par un certains nombres de petites et moyennes entreprises activant dans la région d’Oran, en s’interrogeant sur la manière dont la formation continue a pu ...
Farhaoui Mustafa
doaj +1 more source
[Negative impact of COVID-19 pandemic on peritonitis rate in peritoneal dialysis patients: Pleading for a continuous educational training]. [PDF]
Nephrol Ther, 2022 Jacobs L +9 more
europepmc +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Comment rendre l’Europe plus novatrice
Revue Internationale d’Éducation de Sèvres, 1997 Partageant les analyses sur les transformations de la société de l’industrie en une société de la connaissance, la Confédération européenne des syndicats refuse de laisser au marché seul le soin de réguler l’accès au travail.
Maria-Helena André
doaj +1 more source