Results 111 to 120 of about 484,909 (306)

An Investigation, Using Standard Experimental Techniques, to Determine FLCs at Elevated Temperature for Aluminium Alloys [PDF]

, 2012
An experimental procedure has been developed for the determination of FLCs at elevated temperatures. The GOM ARGUS system was employed for measuring surface strain based on pre-applied grids (pattern), and limit strains were determined according to the ...
Balint, D, Dean, T, Lin, J, Shi, Z, Stanton, M, Wang, Y, Watson, D   +6 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Forming limit diagram of an ultra-thin commercially pure titanium sheet: Combined experimental–numerical approach

Journal of Materials Research and Technology
This study presents a methodology for determining the forming limit diagram (FLD) of an ultra-thin (0.1 mm) commercially pure titanium (CP–Ti) sheet developed for use in metallic bipolar plates for fuel cells.
Kyung Mun Min, Chanyang Kim, Seonghwan Choi, Jong-Hwa Hong, Jinwoo Lee, Hyuk Jong Bong   +5 more
doaj   +1 more source

Prediction of sheet necking with shell finite element models [PDF]

, 2003
In sheet forming simulations, the prediction of localised necking is an important goal. A pragmatic\ud approach is to compare calculated principal strains with a forming limit curve (FLC).
Boogaard, A.H. van den, Huetink, J.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A Chandra and Spitzer census of the young star cluster in the reflection nebula NGC 7129

, 2009
The reflection nebula NGC 7129 has long been known to be a site of recent star formation as evidenced, e.g., by the presence of deeply embedded protostars and HH objects.
A. Scholz, Albacete Colombo, Allen, B. Stelzer, Bechis, Brandt, Cabrit, Calvet, Caramazza, Carpenter, Chiang, D'Alessio, Damjanov, Eiroa, Eiroa, Evans, Evans, Feigelson, Feigelson, Flaccomio, Flaherty, Font, Freeman, Fuente, Fuente, Getman, Getman, Gutermuth, Gutermuth, Gutermuth, Haisch, Hartigan, Hartmann, Herbig, Hernández, Hillenbrand, Indebetouw, Kenyon, Kraft, Lada, Luhman, Magakian, Marigo, Megeath, Meyer, Miranda, Miskolczi, Muzerolle, Predehl, Preibisch, Prisinzano, Racine, Raymond, Reid, Reid, Rieke, Robitaille, Robitaille, Schmitt, Shevchenko, Siess, Stelzer, Stern, Strom, Strom, Vuong, Weintraub, Wood   +67 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The OPTX Project IV: How Reliable is [OIII] as a Measure of AGN Activity?

, 2010
We compare optical and hard X-ray identifications of AGNs using a uniformly selected (above a flux limit of f_2-8 keV = 3.5e-15 erg/cm2/s) and highly optically spectroscopically complete ( > 80% for f_2-8 keV > 1e-14 erg/cm2/s and > 60% below) 2-8 keV ...
A. J. Barger, Alonso-Herrero, Antonucci, Barger, Barger, Bassani, Beckmann, Blanton, Comastri, Cowie, Diamond-Stanic, Ferruit, Hao, Heckman, Heckman, Kakazu, Kewley, L. Trouille, La Franca, La Massa, Laurent-Muehleisen, Meléndez, Moran, Ptak, Reyes, Rigby, Silverman, Steffen, Szokoly, Tremonti, Trouille, Trouille, Ueda, Weedman, Winter, Winter, Yencho, Zakamska   +37 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Similarities and uniqueness of Ly$\alpha$ emitters among star-forming galaxies at z=2.5

, 2017
We conducted a deep narrow-band imaging survey with the Subaru Prime Focus Camera on the Subaru Telescope and constructed a sample of Ly$\alpha$ emitters (LAEs) at z=2.53 in the UDS-CANDELS field where a sample of H$\alpha$ emitters (HAEs) at the same ...
Hayashi, Masao, Kashikawa, Nobunari, Kodama, Tadayuki, Koyama, Yusei, Matsuda, Yuichi, Shibuya, Takatoshi, Shimakawa, Rhythm, Suzuki, Tomoko L., Tadaki, Ken-ichi, Tanaka, Ichi, Yamamoto, Moegi   +10 more
core   +1 more source