Budesonide + formoterol fumarate dihydrate for the treatment of asthma
Expert Opinion on Pharmacotherapy, 2016One of the most widely used fixed combinations in asthma management is dry powder budesonide+formoterol fumarate dihydrate which is commercially available as Symbicort Turbuhaler(®) (and generic products), Easyhaler Bufomix(®) and DuoRespSpiromax(®) inhaler.
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NMR characterisation of structure in solvates and polymorphs of formoterol fumarate
Magnetic Resonance in Chemistry, 2012The solid‐state structures of two polymorphs and two alcoholates (ethanol and isopropanol) of formoterol fumarate have been investigated by a combination of NMR techniques. First‐principles shielding computations are combined with NMR data to successfully relate peaks to their crystallographic positions for the solvates, including atoms that are in ...
David C, Apperley +3 more
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Formoterol Fumarate Inhalation Powder
Hospital Pharmacy, 2001Each month, subscribers to The Formulary® Monograph Service receive five to six researched monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
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Aclidinium bromide/formoterol fumarate as a treatment for COPD: an update
Expert Review of Respiratory Medicine, 2021Introduction: Aclidinium/formoterol is a long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) dual bronchodilator used as a maintenance treatment for patients with chronic obstructive pulmonary disease (COPD). The efficacy of aclidinium/formoterol has been demonstrated consistently in patients with moderate-to-severe COPD versus ...
Anthony D, D'Urzo +4 more
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Nebulized formoterol fumarate: Dose selection and pharmacokinetics
Pulmonary Pharmacology & Therapeutics, 2008To determine a dose of nebulized formoterol fumarate inhalation solution (FFIS) comparable to that of the marketed formoterol fumarate dry powder inhaler (FA, 12microg), two crossover studies were conducted in subjects with COPD. Study 1 was a single-dose, double-blind, double-dummy dose-ranging study in which 47 subjects were randomly assigned to ...
Nicholas J, Gross +7 more
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Formoterol fumarate inhalation solution (Perforomist™) for COPD
Expert Review of Clinical Immunology, 2008Formoterol fumarate is an effective treatment for chronic obstructive pulmonary disease (COPD) patients with moderate or greater severity of airflow obstruction. Published studies indicate that formoterol has a rapid onset of bronchodilation, which may enhance compliance, and sustained bronchodilation over 12 h, which produces a cumulative effect when ...
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Formoterol fumarate + glycopyrrolate for the treatment of chronic obstructive pulmonary disease
Expert Review of Respiratory Medicine, 2016Chronic obstructive pulmonary disease (COPD) is characterized by a high disability and increasing mortality. Bronchodilators are the cornerstone of pharmacological treatment in COPD, while therapeutic optimization with an improvement in symptoms and compliance represent the actual goals. This has led to the development of devices that combine different
D. Radovanovic +6 more
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Effect of formoterol fumarate treatment on exercise-induced bronchoconstriction in children
Annals of Allergy, Asthma & Immunology, 2006Exercise-induced bronchoconstriction (EIB) is common, particularly in children.To compare the protective effect of single doses of formoterol fumarate via Aerolizer with placebo and albuterol in children with EIB.In this randomized, double-blind, double-dummy, crossover trial, 23 children (aged 4-11 years) received formoterol, 12 or 24 microg ...
David, Pearlman +3 more
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Sensitive High Pressure Liquid Chromatographic Assay Method for Formoterol Fumarate
Journal of Liquid Chromatography, 1993Abstract The HPLC method for determination of formoterol uses a 3-μm octyl bonded phase column, 4.6 × 50 mm, and a mobile phase of water-acetonitrile-trifluoroacetic acid in a ratio of 800:200:0.5 (v/v/v) at a flow rate of 2.0 ml/min. The limit of quantitation is 0.02 μg/mL, based on injection of 200-μL aliquots and the average between day coefficient ...
S. J. Graham +2 more
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Quantitative nuclear magnetic resonance analysis of solid formoterol fumarate and its dihydrate
Journal of Pharmaceutical Sciences, 2003Carbon-13 cross-polarization magic-angle spinning nuclear magnetic resonance spectra of anhydrous formoterol fumarate and the dihydrate are presented, together with some relaxation time measurements. The latter enabled quantitation of mixtures of the anhydrate and dihydrate to be made.
David C, Apperley +3 more
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