Results 1 to 10 of about 3,527,229 (316)

The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity

open access: yesmAbs, 2022
Monoclonal antibody (mAb) aggregation can present major challenges for the development of biotherapeutics. An understanding of the molecular mechanisms of mAb aggregation is highly desirable both because it allows the performance of informed risk ...
Michael J. Knight   +4 more
doaj   +1 more source

Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021

open access: yesBulletin of the National Research Centre, 2021
Background Indonesia has started the big project of COVID-19 vaccination program since 13 January 2021 by employing the first shot of vaccine to the President of Indonesia as the outbreak and rapid transmission of COVID-19 have endangered not only ...
Reviany V. Nidom   +10 more
doaj   +1 more source

Pediatric Mini-Tablets: Predicting the Hidden Risk of Fill Errors

open access: yesPharmaceutics, 2023
Compressed mini-tablets in sachets or capsules are an increasingly prevalent oral solid dosage form for pediatric products. While resembling adult tablets, additional care is required to control weight and potency (blend uniformity) variation due to ...
Brandon G. Gerberich   +3 more
doaj   +1 more source

Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the NanopatchTM Microneedle Delivery System

open access: yesHuman Vaccines & Immunotherapeutics, 2021
Measles (Me) and rubella (Ru) viral diseases are targeted for elimination by ensuring a high level of vaccination coverage worldwide. Less costly, more convenient MeRu vaccine delivery systems should improve global vaccine coverage, especially in low ...
Ying Wan   +7 more
doaj   +1 more source

Fish Meal Replacement by Mixed Plant Protein in the Diets for Juvenile Yellow Catfish Pelteobagrus fulvidraco: Effects on Growth Performance and Health Status

open access: yesAquaculture Nutrition, 2022
Increasing dietary replacement levels of fish meal by alternative plant proteins are of value for aquaculture. Here, a 10-week feeding experiment was undertaken to explore the effects of fish meal replacement by mixed plant protein (at a 2 : 3 ratio of ...
Ya-Kang Han   +5 more
doaj   +1 more source

Prediction of long-term polysorbate degradation according to short-term degradation kinetics

open access: yesmAbs, 2023
Polysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of the protein
Sisi Zhang   +8 more
doaj   +1 more source

I. Formulation [PDF]

open access: yesCanadian Psychiatric Association Journal, 1978
The authors describe a systematic approach to the process of formulation. Four interlocking phases are considered. The longitudinal data collection evaluates the patient's developmental journey. The cross-sectional evaluation includes careful consideration of phenomenological and dynamic factors. The integrative evaluation of these factors permits the
S, Kline, P M, Cameron
openaire   +2 more sources

From Sugar to Nutritional Products – Product Form Development

open access: yesCHIMIA, 2021
The formulation of active ingredients into emulsion- and suspension-based delivery systems offers a wide range of opportunities to produce stable and highly bioavailable product forms for their later application in human and animal nutrition.
Theo Ralla   +3 more
doaj   +1 more source

Formulation and preclinical studies with a trivalent rotavirus P2-VP8 subunit vaccine

open access: yesHuman Vaccines & Immunotherapeutics, 2020
More effective rotavirus vaccines are essential for preventing extensive diarrheal morbidity and mortality in children under five years of age in low-resource regions.
Kyle Lakatos   +3 more
doaj   +1 more source

Multisymplectic formulation of vielbein gravity. De Donder-Weyl formulation, Hamiltonian (n-1)-forms [PDF]

open access: yes, 2015
We consider the De Donder-Weyl (DW) Hamiltonian formulation of the Palatini action of vielbein gravity formulated in terms of the solder form and spin connection, which are treated as independent variables.
Vey, Dimitri
core   +4 more sources

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