Results 41 to 50 of about 1,464,537 (295)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Laboratory Animal Research, 2018
Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease.
Jae Young Yu, Hanh Thuy Nguyen, Chul Soon Yong, Hyoung Geun Park, Joon Ho Jun, Jong Oh Kim   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

, 2022
Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress.
Pavan Kumar Nukala, Juluri, Abhishek, Srushti Tambe, Girish Nihalani, Rongala, Gopinath, Meruva, Sai Kishore, Sai Kishore Meruva, Nihalani, Girish, Pradeep Kumar Bolla, Gopinath Rongala, Jain, Divya, Abhishek Juluri, Nukala, Pavan Kumar, Tambe, Srushti, Bolla, Pradeep Kumar, Hemanth Kumar Mamidi, Mamidi, Hemanth Kumar, Divya Jain   +17 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Strategies for Controlling Particle Size in Injectable Nanosuspensions and Emulsions: Techniques and Future Opportunities

Advances in Pharmacological and Pharmaceutical Sciences
Particle size is crucial for injectable nanosuspensions and emulsions, significantly impacting their performance. Achieving optimal particle size is essential in parenteral formulations, and various methods and equipment are available for this purpose ...
Dileep J. Babu Bikkina, Rajesh Vooturi, Subhash Zade, Narendra Reddy Tharigoppala, Suresh Kumar Joshi, Gundawar Ravi   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Formulation and Anorexia Nervosa [PDF]

, 2022
Section A This is a systematic literature review of empirical research investigating the use of formulation in different models of therapy within the treatment of Anorexia Nervosa.
Mountain, L.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Simultaneous Determination of 13 Chemical Marker Compounds in Gwakhyangjeonggi-san, a Herbal Formula, with Validated Analytical Methods

Natural Product Communications, 2014
This study was designed for simultaneous determination of 13 chemical marker compounds, namely, protocatechuic acid, chlorogenic acid, caffeic acid, liquiritin, hesperidin, apigetrin, rosmarinic acid, oxypeucedanin hydrate, byakangelicin, apigenin ...
Jung-Hoon Kim, Hyeun-Kyoo Shin, Chang-Seob Seo   +2 more
doaj   +1 more source