Results 51 to 60 of about 1,464,537 (295)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

RNA-lipid nanoparticle therapeutics for women’s health

Frontiers in Nanotechnology
Ribonucleic acid-lipid nanoparticle (RNA-LNP) therapeutics, a powerful nanomedicine platform, have already demonstrated their efficacy in diverse applications.
Alireza Nomani, Aishwarya Saraswat, Yu Zhang, Ashwin C. Parenky, Chun-Tien Jimmy Kuo, Heather Brown, Suzanne Hartford, Bindhu Rayaprolu, Amardeep Singh Bhupender Bhalla, Mohammed Shameem   +9 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System

Bioengineering
Centralised cell-based biomanufacturing severely limits applicability in low-resource and extreme environments, where a largely untreated human population is present.
Tejasvi Shivakumar, Joshua Clark, Alice Goode, Valentine E. Anyanwu, Philip M. Williams   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Field study on repellent efficacy of Crotalaria burhia Buch.-Ham. ex Benth. and Anacardium occidentale L. against Odontotermes obesus (Rambur)

, 2016
Crotolaria burhia Buch.-Ham. ex Benth. and Anacardium occidentale L. known for their insecticidal properties were tested for their efficacy against the subterranean termite, Odontotermes obesus (Rambur) in wheat and sugarcane fields at Institute of ...
Manoharan, T, Bajya, D R, M, Ranjith ; Tamil Nadu Agricultural University & Institute of Pesticide Formulation Technology   +2 more
core   +1 more source

Evaluation of the Genotoxicity of Bangpungtongsung-San, a Traditional Herbal Prescription [PDF]

Pakistan Veterinary Journal, 2014
Bangpungtongsung-san (BPS) is a traditional Korean herbal formula used as an anti-inflammatory, antipyretic, antiobesity, and choleretic agent, which consists of 18 herbs.
In-Sik Shin, Chang-Seob Seo, Mee-Young Lee, Hye-Kyung Ha, Ji-Young Kim, Jung-Im Huh, Hyeun-Kyoo Shin   +6 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies

mAbs
Monoclonal antibodies (mAbs) feature a conserved N-linked glycosylation site in the CH2 domain, which exhibits heterogeneities in both occupancy and glycan structures. Previous studies have suggested that the unoccupied (nonglycosylated) variant exhibits
Gao-Yuan Liu, Jenny Kim Kim, Shuli Tang, Yuetian Yan, Mandi Hopkins, Dalia Laredo, Teng-Chieh Yang, James Mutino, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Shunhai Wang, Ning Li   +12 more
doaj   +1 more source

Quality Assessment of Ojeok-San, a Traditional Herbal Formula, Using High-Performance Liquid Chromatography Combined with Chemometric Analysis

Journal of Analytical Methods in Chemistry, 2015
Ojeok-san (OJS) is a traditional herbal formula consisting of 17 herbal medicines that has been used to treat various disorders. In this study, quantitative analytical methods were developed using high-performance liquid chromatography equipped with a ...
Jung-Hoon Kim, Chang-Seob Seo, Seong-Sil Kim, Hyeun-Kyoo Shin   +3 more
doaj   +1 more source