Results 91 to 100 of about 3,527,229 (316)

Formulation and evaluation of mucoadhesive glipizide microspheres [PDF]

, 2005
Jayvadan K. Patel, Rakesh Patel, Avani Amin, Madhabhai M. Patel   +3 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

PROPERMAB: an integrative framework for in silico prediction of antibody developability using machine learning

mAbs
Selection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated only ...
Bian Li, Shukun Luo, Wenhua Wang, Jiahui Xu, Dingjiang Liu, Mohammed Shameem, John Mattila, Matthew C. Franklin, Peter G. Hawkins, Gurinder S. Atwal   +9 more
doaj   +1 more source

Strategies to Maximize the Potential of Marine Biomaterials as a Platform for Cell Therapy

Marine Drugs, 2016
Marine biopolymers have been explored as a promising cell therapy system for efficient cell delivery and tissue engineering. However, the marine biomaterial-based systems themselves have exhibited limited performance in terms of maintenance of cell ...
Hyeongmin Kim, Jaehwi Lee
doaj   +1 more source

Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time In Situ Release Kinetics in Peptide-Liposome Formulations

, 2021
Camille Doyen, Éric Larquet, Pierre‐Damien Coureux, Oriane Frances, Frédéric Herman, Serge Sablé, Jean-Pierre Burnouf, Christina Sizun, Ewen Lescop   +8 more
openalex   +2 more sources

Efficacy, safety and acceptability of a new chewable formulation versus the solid tablet of mebendazole against hookworm infections in children: An open-label, randomized controlled trial [PDF]

, 2020
Marta S. Palmeirim, Fèlix Bosch, M. Shaali, Said M. Ali, Jan Hattendorf, Jennifer Keiser   +5 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer’s Disease

Molecules
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, synaptic loss, and multifaceted pathology involving amyloid-β (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, and impaired ...
Huan Li, Xinai Shen, Beiyu Zhang, Zheying Zhu   +3 more
doaj   +1 more source

Isolation and identification of cellulose demoting symbionts from gut of subterranean termite, Odontotermes obesus

The Indian Journal of Agricultural Sciences, 2015
The study was carried out to isolate and identify the symbionts, viz. cellulose demoting bacteria and fungus in termite gut. The experiment was conducted during (February 2013- July 2013) at biotechnology laboratory, Institute of Pesticide Formulation ...
D R BAJYA, DEEPIKA ARYA, M RANJITH, M C LAKHARAN, S K RAZA   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source