Results 51 to 60 of about 1,897,075 (291)

RNA-lipid nanoparticle therapeutics for women’s health

Frontiers in Nanotechnology
Ribonucleic acid-lipid nanoparticle (RNA-LNP) therapeutics, a powerful nanomedicine platform, have already demonstrated their efficacy in diverse applications.
Alireza Nomani, Aishwarya Saraswat, Yu Zhang, Ashwin C. Parenky, Chun-Tien Jimmy Kuo, Heather Brown, Suzanne Hartford, Bindhu Rayaprolu, Amardeep Singh Bhupender Bhalla, Mohammed Shameem   +9 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Quality Assessment of Ojeok-San, a Traditional Herbal Formula, Using High-Performance Liquid Chromatography Combined with Chemometric Analysis

Journal of Analytical Methods in Chemistry, 2015
Ojeok-san (OJS) is a traditional herbal formula consisting of 17 herbal medicines that has been used to treat various disorders. In this study, quantitative analytical methods were developed using high-performance liquid chromatography equipped with a ...
Jung-Hoon Kim, Chang-Seob Seo, Seong-Sil Kim, Hyeun-Kyoo Shin   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System

Bioengineering
Centralised cell-based biomanufacturing severely limits applicability in low-resource and extreme environments, where a largely untreated human population is present.
Tejasvi Shivakumar, Joshua Clark, Alice Goode, Valentine E. Anyanwu, Philip M. Williams   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Unlocking norepinephrine potential innovations in formulation and smart systems

Discover Pharmaceutical Sciences
Norepinephrine (NE), a critical neurotransmitter and hormone, profoundly influences cardiovascular function and stress response. However, inherent pharmacokinetic challenges, notably rapid enzymatic degradation and a short half-life, mandate continuous ...
Samarth Kumar, Sachin N. Sanap, Milan Vasoya, Prachi Pandey, Ajay Khopade, Krutika K. Sawant   +5 more
doaj   +1 more source

The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies

mAbs
Monoclonal antibodies (mAbs) feature a conserved N-linked glycosylation site in the CH2 domain, which exhibits heterogeneities in both occupancy and glycan structures. Previous studies have suggested that the unoccupied (nonglycosylated) variant exhibits
Gao-Yuan Liu, Jenny Kim Kim, Shuli Tang, Yuetian Yan, Mandi Hopkins, Dalia Laredo, Teng-Chieh Yang, James Mutino, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Shunhai Wang, Ning Li   +12 more
doaj   +1 more source

20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1–AMP-activated protein kinase activation

Journal of Ginseng Research, 2017
Background: Previously, we reported that Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs).
Sang Mi Park, Eun Hye Jung, Jae Kwang Kim, Kyung Hwan Jegal, Chung A Park, Il Je Cho, Sang Chan Kim   +6 more
doaj   +1 more source

Formulation, stabilisation and encapsulation of bacteriophage for phage therapy.

Advances in Colloid and Interface Science, 2017
Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurgent interest in the potential use of bacteriophages for therapeutic purposes, known as phage therapy.
D. Malik, I. J. Sokolov, Gurinder K. Vinner, F. Mancuso, Salvatore Cinquerrui, G. Vladisavljević, M. Clokie, N. Garton, A. Stapley, Anna Kirpichnikova   +9 more
semanticscholar   +1 more source