Formyl peptide receptors in the mucosal immune system [PDF]
Experimental and Molecular Medicine, 2020 Formyl peptide receptors: Receptors in the mucosal immune system Key receptors in defense against bacteria may also be attractive targets for diseases of the mucosa, the tissue that lines and protects areas such as the airways and gastrointestinal tract.
Yu Sun Jeong, Yoe-Sik Bae
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Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease [PDF]
Frontiers in Immunology, 2021 Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva +10 more
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Formyl peptide receptors in bone research. [PDF]
Connect Tissue Res, 2023 The formyl peptide receptor (FPR) participates in the immune response, with roles in infection and inflammation. In this review article, we summarize the current literature on these roles before discussing the function of FPRs in the pathogenesis of musculoskeletal disorders including osteoarthritis (OA), degenerative disc disease (DDD), and rheumatoid
Lantieri MA +5 more
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Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice [PDF]
Membranes, 2023 The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood.
Irina Tikhonova +3 more
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Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. [PDF]
PLoS ONE, 2014 Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
Irene Gallo +7 more
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The Role of Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation [PDF]
Frontiers in Cellular Neuroscience, 2021 Formyl peptide receptors (FPRs) are a group of G protein-coupled cell surface receptors that play important roles in host defense and inflammation. Owing to the ubiquitous expression of FPRs throughout different cell types and since they interact with ...
Jiahui Zhu +5 more
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The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity [PDF]
Journal of Innate Immunity, 2021 Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either ...
Jonas Mårtensson +8 more
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Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Life, 2022 Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood ...
Edward S. Wickstead +2 more
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Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression [PDF]
Life, 2021 G protein-coupled receptors (GPCRs) are the most important regulators of cardiac function and are commonly targeted for medical therapeutics. Formyl-Peptide Receptors (FPRs) are members of the GPCR superfamily and play an emerging role in cardiovascular ...
Valentina Maria Caso +9 more
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The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? [PDF]
Frontiers in Immunology, 2021 Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a progressive symmetric inflammation of the joints resulting in bone erosion and cartilage destruction with a progressive loss of function and joint deformity. An increased number
Ilaria Mormile +8 more
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