Results 71 to 80 of about 9,630 (159)

Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase

Frontiers in Immunology, 2019
Despite recent advances in our understanding of the mechanisms underlying systemic inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to these critically ill patients is centered around supportive care including fluid ...
Patricia Martinez-Quinones, Patricia Martinez-Quinones, Amel Komic, Amel Komic, Cameron G. McCarthy, R. Clinton Webb, Camilla Ferreira Wenceslau   +6 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

Frontiers in Pharmacology, 2019
The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) in vivo.
Cheng Xue Qin, Cheng Xue Qin, Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Mitchel Tate, Amy E. Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man K. S. Lee, Jane E. Bourke, Yuan Yang, Andrew J. Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H. Ritchie, Rebecca H. Ritchie, Rebecca H. Ritchie, Rebecca H. Ritchie   +23 more
doaj   +1 more source

Dynamic Evolution of Bacterial Ligand Recognition by Formyl Peptide Receptors. [PDF]

Genome Biol Evol, 2023
Paterson NM, Al-Zubieri H, Ragona J, Kohler KM, Tirado J, Geisbrecht BV, Barber MF.   +6 more
europepmc   +1 more source

Assessing the potential of bacterial signal peptides for radiopharmaceutical applications

Scientific Reports
Bacterial signal peptides are a large group of high-affinity ligands for formyl peptide receptors (FPRs). These receptors are highly enriched on the surface of glioblastomas and several other tumor types.
Zukaa Al Taleb, Ina Hierlmeier, Heiko Heilmann, Martin Jung, Mark Bartholomä, Bernd Bufe   +5 more
doaj   +1 more source

Solubilization and Display of G Protein-Coupled Receptors on Beads for Real-Time Fluorescence and Flow Cytometric Analysis

BioTechniques, 2000
G protein-coupled receptors (GPCR) and cellular signaling elements are prime targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities for these elements can play significant roles in basic research and drug discovery.
L.A. Sklar, J. Vilven, E. Lynam, D. Neldon, T.A. Bennett, E. Prossnitz   +5 more
doaj   +1 more source

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

British Journal of Pharmacology
Background and PurposeThe pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher   +5 more
openaire   +2 more sources

Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis

Thrombosis Journal
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on the nature of stimulating ligand type. FPRs have been shown to be present in platelets and regulate their
Shatha AlOmar, Joanne L Mitchell, Eman AlZahrani   +2 more
doaj   +1 more source

Protective and Pain-Killer Effects of AMC3, a Novel N-Formyl Peptide Receptors (FPRs) Modulator, in Experimental Models of Rheumatoid Arthritis. [PDF]

Antioxidants (Basel), 2023
Ferrara V, Toti A, Lucarini E, Parisio C, Micheli L, Ciampi C, Margiotta F, Crocetti L, Vergelli C, Giovannoni MP, Di Cesare Mannelli L, Ghelardini C.   +11 more
europepmc   +1 more source

Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors. [PDF]

Int J Mol Sci, 2021
Cuomo P, Medaglia C, Allocca I, Montone AMI, Guerra F, Cabaro S, Mollo E, Eletto D, Papaianni M, Capparelli R.   +9 more
europepmc   +1 more source