Results 91 to 100 of about 26,336 (149)

Noradrenaline Synergistically Enhances <i>Porphyromonas gingivalis</i> LPS and OMV-Induced Interleukin-1<i>β</i> Production in BV-2 Microglia Through Differential Mechanisms. [PDF]

Int J Mol Sci
Muramoto S, Shimizu S, Shirakawa S, Ikeda H, Miyamoto S, Jo M, Takemori U, Morimoto C, Wu Z, Tozaki-Saitoh H, Oda K, Inoue E, Nonaka S, Nakanishi H.   +13 more
europepmc   +1 more source

A Novel Cognitive Frailty Index for Geriatric Mice

Aging Cell, EarlyView.
Our study presents a groundbreaking longitudinal assessment of age‐related cognitive decline in a large cohort of aged mice. Through the development of the Cognitive Frailty Index (CoFI), we introduce a robust metric that correlates strongly with advancing age and mortality.
Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai, Beatrice Bartozzi, Marta Balietti, Tiziana Casoli, Fiorenza Orlando, Andrea Amoroso, Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Fabrizia Lattanzio, Fabiola Olivieri, Peter L. J. de Keizer, Fabrizio d’Adda di Fagagna, Marco Malavolta   +16 more
wiley   +1 more source

Protocol for labeling and manipulating "home"-activated neurons in mice. [PDF]

STAR Protoc
Su X, He J, Liu Y, Liu K, Lei B, Zhong Y.   +5 more
europepmc   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Blood transcriptomic signatures associated with depression, or the risk for depression, in pregnant women from the Psychiatry Research And Motherhood - Depression (PRAM-D) study. [PDF]

Transl Psychiatry
Di Benedetto MG, Priestley KMS, Cattane N, Genini P, Saleri S, Biaggi A, Bind RH, Conroy S, Du Preez A, Hazelgrove K, Osborne S, Pawlby S, Sethna V, Pariante CM, Cattaneo A.   +14 more
europepmc   +1 more source

Ethanol‐induced Nrf2 suppression in the lung is mediated by AP‐1‐driven expression of miR‐144

Alcohol, Clinical and Experimental Research, EarlyView.
Previously, we determined that ethanol suppresses Nrf2 and thereby inhibits antioxidant and immune defenses in the lung. Clinically, individuals with AUD are vulnerable to pneumonia and acute lung injury. In this new experimental study, we report that ethanol inhibits Nrf2 in rat lung cells via the induction of miR‐144 in a mechanism dependent on the ...
Viranuj Sueblinvong, Xian Fan, Justin Guo, Hui Tao, David M. Guidot   +4 more
wiley   +1 more source

Trending extinctions: online interest in recently extinct animals

Animal Conservation, EarlyView.
When species go extinct, online interest spikes but often fades quickly. We analysed how online attention shifts before and after extinction announcements of eight species and found that there are brief spikes of interest on Twitter, while Wikipedia shows more prolonged engagement.
S. Canavan, D.M. Doyle, A. Kane, G. Nolan, K. Healy   +4 more
wiley   +1 more source

Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson's disease. [PDF]

J Cereb Blood Flow Metab
Lungu R, Fernandes FF, Pires Monteiro S, Outeiro TF, Shemesh N.   +4 more
europepmc   +1 more source

Regulation of the MAPK/ERK Pathway by miRNA‐27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
wiley   +1 more source

TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma. [PDF]

Cell Rep
So CL, Lee YJ, Vokshi BH, Chen W, Huang B, De Sousa E, Gao Y, Portuallo ME, Begum S, Jagirdar K, Linehan WM, Rebecca VW, Ji H, Toska E, Cai D.   +14 more
europepmc   +1 more source