Results 11 to 20 of about 29,282 (210)

Formulation, development and characterization of fosfomycin tromethamine pessaries for the treatment of vaginal infections [PDF]

Scientific Reports
Background The present study investigated the formulation, development, and characterization of Fosfomycin pessaries for the treatment of genitourinary tract infections. To achieve higher local concentration and to avoid the systemic exposure of the body
Mahboob Ul Haq, Attiqa Naz, Abdul Baseer, Sajjad Ahmad, Basmah F. Alharbi, Muhammad Khurram   +5 more
doaj   +2 more sources

Fosfomycin: Pharmacological, Clinical and Future Perspectives

Antibiotics, 2017
Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis ...
Jacobus Burggraaf, Cees van Nieuwkoop, Jasper Stevens   +2 more
exaly   +3 more sources

Fosfomycin [PDF]

Clinical Microbiology Reviews, 2016
SUMMARY The treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new antibiotics active against such MDR and XDR bacteria.
Matthew E, Falagas, Evridiki K, Vouloumanou, George, Samonis, Konstantinos Z, Vardakas   +3 more
  +6 more sources

Glucose-6-phosphate Reduces Fosfomycin Activity Against Stenotrophomonas maltophilia

Frontiers in Microbiology, 2022
It is generally accepted that fosfomycin activity is higher in the presence of glucose-6-phosphate, since its inducible transporter UhpT is one of the gates for fosfomycin entry.
Teresa Gil-Gil, Teresa Gil-Gil, José Luis Martínez   +2 more
doaj   +1 more source

Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli

Microbiology Spectrum, 2023
Fosfomycin is used to treat a variety of bacterial infections, including urinary tract infections caused by Escherichia coli. In recent years, quinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria have been increasing.
Hidetada Hirakawa, Ayako Takita, Yumika Sato, Suguru Hiramoto, Yusuke Hashimoto, Noriyasu Ohshima, Yoji A. Minamishima, Masami Murakami, Haruyoshi Tomita   +8 more
doaj   +1 more source

In Vitro and In Vivo Synergism of Fosfomycin in Combination with Meropenem or Polymyxin B against KPC-2-Producing Klebsiella pneumoniae Clinical Isolates

Antibiotics, 2023
Fosfomycin disodium is a potential therapeutic option to manage difficult-to-treat infections, especially when combined with other antimicrobials. In this study, we evaluated the activity of fosfomycin in combination with meropenem or polymyxin B against
Aghata Cardoso da Silva Ribeiro, Yohanna Carvalho dos Santos Aoun Chikhani, Tiago Barcelos Valiatti, André Valêncio, Mariana Neri Lucas Kurihara, Fernanda Fernandes Santos, Luciene Andrade da Rocha Minarini, Ana Cristina Gales   +7 more
doaj   +1 more source

Effect of Glycerol on Fosfomycin Activity against Escherichia coli

Antibiotics, 2022
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels (UhpT and GlpT). Glycerol is clinically used as a treatment for elevated intracranial pressure and induces the expression of glpT
Miriam Ortiz-Padilla, Inés Portillo-Calderón, Ana Velázquez-Escudero, Jesús Rodríguez-Baño, Álvaro Pascual, José Manuel Rodríguez-Martínez, Fernando Docobo-Pérez   +6 more
doaj   +1 more source

Evaluation of the Synergistic Antibacterial Effects of Fosfomycin in Combination with Selected Antibiotics against Carbapenem–Resistant Acinetobacter baumannii

Pharmaceuticals, 2021
The spread of multi-drug resistant (MDR) pathogens and the lagging pace in the development of novel chemotherapeutic agents warrant the use of combination therapy as a reliable, cost-effective interim option.
Ozioma F. Nwabor, Pawarisa Terbtothakun, Supayang P. Voravuthikunchai, Sarunyou Chusri   +3 more
doaj   +1 more source

The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study

Infectious Diseases and Therapy, 2023
Introduction High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE.
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Asp50Glu mutation in MurA results in fosfomycin resistance in Enterococcus faecium

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Enterococcus faecium is one of the important pathogens causing nosocomial infection, which can be resistant to fosfomycin by obtaining the plasmid-encoded fosfomycin resistance genes, and the mutation of MurA protein encoded by chromosome ...
Ling Xin, Zetao Hu, Renru Han, Xiaogang Xu, Chuning Wang, Dan Li, Yan Guo, Fupin Hu   +7 more
doaj   +1 more source