Results 11 to 20 of about 36,369 (248)
Fosfomycin: Pharmacological, Clinical and Future Perspectives
Antibiotics, 2017 Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis ...
Jacobus Burggraaf +2 more
exaly +3 more sources
Antimicrobial Agents and Chemotherapy, 2019 Multidrug-resistant (MDR) Gram-negative organisms are a major health concern due to lack of effective therapy. Emergence of resistance to newer agents like ceftazidime-avibactam (CZA) further magnifies the problem. In this context, combination therapy of
Razieh Kebriaei, Mariana Castanheira
exaly +2 more sources
Tropical Medicine and Infectious Disease, 2022 Urinary tract infections (UTI) are a severe public health problem and are caused mainly by the uropathogenic Escherichia coli (UPEC). Antimicrobial resistance and limited development of new antimicrobials have led to the reuse of old antibiotics such as ...
Haziel Eleazar Dzib-Baak +5 more
doaj +2 more sources
Evaluation of Inhaled Colistin/Fosfomycin as an Adjunctive Treatment for Ventilator-Associated Pneumonia: A Preliminary Study. [PDF]
Health Sci RepABSTRACT Background and Aims Ventilator‐associated pneumonia (VAP) caused by gram‐negative bacteria is associated with significant complications, mortality, and resource utilization. Over the past decade, there has been growing interest in using fosfomycin to treat multidrug‐resistant gram‐negative infections, particularly when limited viable options ...
Hakamifard A +6 more
europepmc +2 more sources
Glucose-6-phosphate Reduces Fosfomycin Activity Against Stenotrophomonas maltophilia
Frontiers in Microbiology, 2022 It is generally accepted that fosfomycin activity is higher in the presence of glucose-6-phosphate, since its inducible transporter UhpT is one of the gates for fosfomycin entry.
Teresa Gil-Gil +2 more
doaj +1 more source
Infection and Drug Resistance, 2023 Introduction A considerable number of morbidities and fatalities occur worldwide as a result of the multidrug resistant microorganisms that cause a high prevalence of nosocomial bacterial infections.
M. Aljeldah +3 more
semanticscholar +1 more source
Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
Frontiers in Cellular and Infection Microbiology, 2023 Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been necessary.
V. Mattioni Marchetti +2 more
semanticscholar +1 more source
Pathogens, 2023 Acinetobacter baumannii (AB) has evolved over the last decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in the intensive care unit (ICU).
S. Assimakopoulos +8 more
semanticscholar +1 more source
Microorganisms, 2023 The drug resistance of bacterial pathogens causes considerable morbidity and death globally, hence there is a crucial necessity for the development of effective antibacterial medicines to address the antibacterial resistance issue.
K. S. Almaary +5 more
semanticscholar +1 more source
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Antibiotics, 2022 Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels (UhpT and GlpT). Glycerol is clinically used as a treatment for elevated intracranial pressure and induces the expression of glpT
Miriam Ortiz-Padilla +6 more
doaj +1 more source