Results 41 to 50 of about 22,313 (170)

Fosfomycin Resistance in Avian Pathogenic Escherichia coli Isolates

Journal of Integrative Agriculture, 2012
Fosfomycin, a broad-spectrum antibiotic against both Gram-positive and Gram-negative bacteria, is very important in the clinic but many fosfomycin-resistant bacteria have been isolated from patients.
Wen-jie JIN, Zhi-ming ZHENG, Qian-qian WANG, Ai-jian QIN, Hong-xia SHAO, Kun QIAN   +5 more
doaj   +1 more source

Effective Treatment for Uncomplicated Urinary Tract Infections with Oral Fosfomycin, Single Center Four Year Retrospective Study

Antibiotics, 2020
Fosfomycin represents a relatively old antibiotic, but it is experiencing a comeback in recent years. According to some studies, the increasing therapeutic use of this drug led to a rapid increase in the levels of resistance in bacteria causing urinary ...
Miroslav Fajfr, Michal Balik, Eva Cermakova, Pavel Bostik   +3 more
doaj   +1 more source

Screening for Fosfomycin Resistance Genes in Carbapenem- Resistant Isolates of Enterobacterales from the Bloodstream of Liver Transplant Patients

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2022
Introduction: Interest in fosfomycin, an old antibiotic, has been reignited because of the use of its intravenous formulation (fosfomycin sodium) in resistant infections.
Yakup GEZER, Elif Seren TANRIVERDİ, Barış OTLU, Sezai YILMAZ, Yaşar BAYINDIR   +4 more
doaj   +1 more source

Structural and Biochemical Insights into the Mechanism of Fosfomycin Phosphorylation by Fosfomycin Resistance Kinase FomA

, 2016
We present here the crystal structures of fosfomycin resistance protein (FomA) complexed with MgATP, with ATP and fosfomycin, with MgADP and fosfomycin vanadate, with MgADP and the product of the enzymatic reaction, fosfomycin monophosphate, and with ADP
Marcia E. Newcomer (1332279), Pamela A. Doerner (2176346), Svetlana Pakhomova (1332282), Sue G. Bartlett (2176344)   +3 more
core   +2 more sources

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Formulation, development and characterization of fosfomycin tromethamine pessaries for the treatment of vaginal infections

Scientific Reports
Background The present study investigated the formulation, development, and characterization of Fosfomycin pessaries for the treatment of genitourinary tract infections. To achieve higher local concentration and to avoid the systemic exposure of the body
Mahboob Ul Haq, Attiqa Naz, Abdul Baseer, Sajjad Ahmad, Basmah F. Alharbi, Muhammad Khurram   +5 more
doaj   +1 more source

Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae

iMeta, EarlyView.
Transient exposure to ampicillin results in restructuring of microbiota to favor oxygen‐tolerant bacteria, whereas osmotic laxative perturbation preserves Bacteriodota. Ampicillin‐ but not laxative‐exposed environment favors establishment of rmpA phase variants that lost hypermucoviscosity but short‐chain fatty acids present in the laxative‐exposed gut
Carey Lim, Jialing Zheng, Guoxiang Cheam, Melvin Yong, Hanrong Chen, Andrew Ting, Yahua Chen, Qingqing Wang, Niranjan Nagarajan, Yunn‐Hwen Gan   +9 more
wiley   +1 more source

Clinical Use of Intravenous Fosfomycin in Critical Care Patients in Taiwan

Pathogens, 2023
This retrospective study aimed to evaluate the clinical use and side effects of fosfomycin in critically ill patients in Taiwan. Forty-two patients (mean age, 69.9 years; female, 69%) who received fosfomycin were included from a teaching hospital in ...
Tzu-Ting Chen, Yun-Fu Chang, Yea-Chwen Wu   +2 more
doaj   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

In vitro synergy with fosfomycin plus doxycyclin against linezolid and vancomycin-resistant Enterococcus faecium

Journal of Global Antimicrobial Resistance, 2020
Objective: Linezolid and vancomycin-resistant Enterococcus faecium (LRVREF) is globally emerging as a urinary nosocomial pathogen. A decrease in the amount of successful treatment options has created a necessity for the development of novel antimicrobial
Heather Davis, Ryan Brown, Deborah Ashcraft, George Pankey   +3 more
doaj   +1 more source