Results 61 to 70 of about 17,034 (166)

Efficacy of high doses of intravenous fosfomycin for treatment of urinary tract infection caused by KPC carbapenemase-producing Klebsiella pneumoniae: An observational study

Journal of Global Antimicrobial Resistance
: Objective: To evaluate the efficacy of high-dose intravenous fosfomycin for the treatment of urinary tract infections (UTI) caused by KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp).
Jorge Rodríguez-Gómez, Irene Gracia-Ahufinger I, Rosario Carmona-Flores, Julia Guzmán-Puche, Rafael León, Elena Pérez-Nadales, Monserrat Muñoz de la Rosa, Alejandra Mendez Natera, Juan José Castón, Ángela Cano, Juan Jesús Pineda-Capitán, Cristina López, Carmen De la Fuente-Martos, Julián Torre-Cisneros, Luis Martínez-Martínez   +14 more
doaj   +1 more source

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, Volume 138, Issue 1, Page 33-44, July 2026.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Antimicrobial susceptibilities of clinical bacterial isolates from urinary tract infections to fosfomycin and comparator antibiotics determined by agar dilution method and automated micro broth dilution

Microbiology Spectrum
Uncomplicated bacteremic urinary tract infections (bUTIs) are common, often caused by Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis, with most encounters treated empirically.
Jamie L. Dombach, Nancy C. Smith, Teresa Kottiri, Alicia M. Schiller, Edwin Kamau   +4 more
doaj   +1 more source

Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection: A Multicentre, Pragmatic, Randomized Trial—Vanguard Results

Journal of the American Geriatrics Society, Volume 74, Issue 7, Page 1964-1970, July 2026.
ABSTRACT Background It is unclear whether antibiotics improve outcomes for older adults with delirium who have pyuria or bacteriuria in the absence of other signs or symptoms of a urinary tract infection. Methods Our study is a multicenter, parallel‐group, single‐blinded, non‐inferiority pragmatic randomized trial.
Michael Fralick, Nathan M. Stall, Katarina Zorcic, Christina Reppas‐Rindlisbacher, Eric Kaplovitch, Amy S. Li, Derek R. MacFadden, Daniel Kobewka, Lucas Castellani, Patricia Parsons, Allison McGeer, Janine McCready, Bryant Lim, Emil Hodzic‐Santor, Christopher Kandel, for the A‐DONUT Study Team, Hania Siddiqui, Harshita Chaudhary, Afsaneh Raissi, Tamara Van Bakel, Maureen Taylor, Enoch Choo, Sharrmini Chandrasegaram, Natalie Walde, Irene Amadu, Logan Coccimiglio, Malaz Idris   +26 more
wiley   +1 more source

Characterization of fosS, a novel fosfomycin-modifying enzyme gene identified in Staphylococcus haemolyticus

One Health Advances
The efficacy of fosfomycin is increasingly challenged by emerging resistance mechanisms, primarily involving fosfomycin-modifying enzymes and target (MurA) alterations. This study aimed to elucidate the novel mechanism underlying fosfomycin resistance in
Honghao Huang, Huan Chen, Ruonan Zhao, Yiyi Chen, Jianxin Hu, Peng Wan, Lingxuan Zhang, Wengaung Xiong, Yan Chen, Yafei Li, Zhenling Zeng   +10 more
doaj   +1 more source

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2016
Fosfomycin is a new agent to Canada approved for the treatment of acute uncomplicated cystitis (AUC) in adult women infected with susceptible isolates of E. coli and Enterococcus faecalis.
George G. Zhanel, Andrew J. Walkty, James A. Karlowsky   +2 more
doaj   +1 more source

Fosfomycin susceptibility of uropathogens at Charlotte Maxeke Johannesburg Academic Hospital

Southern African Journal of Infectious Diseases, 2020
Background: Multidrug-resistant uropathogens are becoming widespread both in community and hospital setting. Safe yet effective treatments are a priority.
Lesego M. Mothibi, Norma N. Bosman, Trusha Nana   +2 more
doaj   +1 more source

Identification of a novel chromosome-encoded fosfomycin resistance gene fosC3 in Aeromonas caviae

Frontiers in Microbiology
BackgroundOwing to the rapid emerging of multidrug-, even pandrug-resistant pathogens, and lack of new antibiotics, the older antibiotic, fosfomycin, has been reused in recent years in the clinical practice, especially for treatment of uropathogen ...
Junwan Lu, Junwan Lu, Runzhi Zhang, Yan Yu, Hongqiang Lou, Dong Li, Qiyu Bao, Qiyu Bao, Chunlin Feng   +8 more
doaj   +1 more source

In vitro efficacy of fosfomycin against clinical strains [PDF]

Journal of Microbiology and Infectious Diseases, 2014
Objective: Fosfomycin is an alternative drug for treatment of uncomplicated urinary tract infections. This study aimed to investigate in vitro activity of fosfomycin against ethicillinresistant Staphylococcus aureus (MRSA), methicillinresistant ...
Adil Karadağ , Yeliz Tanrıverdi Çaycı , Kemal Bilgin , Murat Günaydın, Cafer Eroğlu   +4 more
doaj  

Monitoring Plasma Concentrations of Intravenously Administered Fosfomycin to Prevent Drug-Related Adverse Events: A Retrospective Observational Study

Antibiotics
Background: Fosfomycin is used as a combination partner for the treatment of severe non-urinary tract infections. Individualized dosing of fosfomycin based on therapeutic drug monitoring (TDM) has the potential to reduce drug-related adverse events (AEs).
Kathrin Marx, Nina Malmström, Marie Quast, Annette Glas, Ralph Wendt, Martina Kinzig, Fritz Sörgel, Maike Fedders, Thilo Bertsche, Christoph Lübbert   +9 more
doaj   +1 more source