Results 11 to 20 of about 22,313 (170)

Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence

Future Science OA, 2020
Aim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this
Yamuna Devi Bakthavatchalam, Abirami Shankar, Dhiviya Prabaa Muthuirulandi Sethuvel, Kalaiarasi Asokan, Kalaiarasi Kanthan, Balaji Veeraraghavan   +5 more
doaj   +2 more sources

Update on fosfomycin-modified genes in Enterobacteriaceae

Journal of Microbiology, Immunology and Infection, 2019
The long-used antibiotic fosfomycin has recently been re-evaluated as a potential regimen for treating extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE).
Tsung-Ying Yang, Po-Liang Lu, Sung-Pin Tseng   +2 more
doaj   +2 more sources

Plasma and Urine Pharmacokinetics of Oral Fosfomycin Tromethamine in Dogs

Veterinary Sciences, 2023
Fosfomycin is a broad-spectrum, bactericidal antibiotic with low toxicity. It has been used in human medicine and is a promising candidate for treating infections in veterinary medicine.
Nattha Jariyapamornkoon, Koranis Patthanachai, Nipattra Suanpairintr   +2 more
doaj   +2 more sources

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 2016
Fosfomycin is a new agent to Canada approved for the treatment of acute uncomplicated cystitis (AUC) in adult women infected with susceptible isolates of E. coli and Enterococcus faecalis.
George G. Zhanel, Andrew J. Walkty, James A. Karlowsky   +2 more
doaj   +2 more sources

Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae [PDF]

, 2021
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin.
Blázquez, J., De Gregorio Iaria, Belén, Docobo Pérez, Fernando, Ortiz Padilla, M., Rodríguez-Baño, Jesús, Pascual Hernández, Álvaro, Portillo Calderón, I., Rodríguez Martínez, José Manuel   +7 more
core   +3 more sources

Molecular mechanisms and epidemiology of fosfomycin resistance in enterococci isolated from patients at a teaching hospital in China, 2013–2016

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to investigate the mechanisms of fosfomycin resistance and epidemiological characteristics in fosfomycin-resistant enterococci in China.
Xiucai Zhang, Wenzi Bi, Lijiang Chen, Yizhi Zhang, Renchi Fang, Jianming Cao, Tieli Zhou   +6 more
doaj   +1 more source

In vitro activity of fosfomycin against Campylobacter isolates from poultry and wild birds. [PDF]

PLoS ONE, 2018
Fosfomycin is a broad-spectrum antibiotic with the activity against both Gram-positive and Gram-negative pathogens by inhibiting the bacterial cell wall synthesis. Given the potential therapeutic efficacy of fosfomycin against Campylobacter spp., the aim
Bai Wei, Min Kang
doaj   +1 more source

Activity of Fosfomycin and Amikacin against Fosfomycin-Heteroresistant Escherichia coli Strains in a Hollow-Fiber Infection Model

, 2021
We evaluated human-like the efficacy of intravenous doses of fosfomycin of 8 g every 8 h (8 g/Q8h) and of amikacin (15 mg/kg/Q24h) in monotherapy and in combination against six fosfomycin-heteroresistant Escherichia coli isolates using a hollow-fiber ...
Blázquez, J., De Gregorio Iaria, Belén, Docobo Pérez, Fernando, Merino Bohórquez, Vicente, Rodríguez-Baño, Jesús, Ortiz Padilla, Miriam, Pascual Hernández, Álvaro, Portillo Calderón, I., Rodríguez Martínez, José Manuel   +8 more
core   +2 more sources

Molecular characterization of fosfomycin-resistant Escherichia coli urinary tract infection isolates from Australia (Letter)

, 2021
Fosfomycin is a broad-spectrum antibiotic that targets UDP-Nacetylglucosamine enolpyruvyl transferase (MurA), an important enzyme in the early stages of peptidoglycan biosynthesis. In Escherichia coli, fosfomycin resistance can occur through the presence
Daley, DA, Peachey, G, Gottlieb, T, Bradbury, S, Korman, T, Coombs, GW, Streitberg, R, Mowlaboccus, S, Birdsall, J, Merlino, J, Robson, J, Collignon, P, George, N, Rogers, BA, Nimmo, GR   +14 more
core   +1 more source

fosA3 overexpression with transporter mutations mediates high-level of fosfomycin resistance and silence of fosA3 in fosfomycin-susceptible Klebsiella pneumoniae producing carbapenemase clinical isolates.

PLoS ONE, 2020
The effective treatment of carbapenemase-producing Klebsiella pneumoniae infection has been limited and required novel potential agents. Due to the novel drug development crisis, using old antimicrobial agents and combination therapy have been ...
Uthaibhorn Singkham-In, Netchanok Muhummudaree, Tanittha Chatsuwan   +2 more
doaj   +1 more source