Results 11 to 20 of about 29,630 (214)
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Antibiotics, 2022 Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels (UhpT and GlpT). Glycerol is clinically used as a treatment for elevated intracranial pressure and induces the expression of glpT
Miriam Ortiz-Padilla +6 more
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Fosfomycin in Osteomyelitis [PDF]
Chemotherapy, 1976 Fosfomycin was exclusively used as antibiotic treatment in 37 patients suffering from osteomyelitis, out ot which 23 were operated for sequestrectomy or fistulectomy, whereas the remaining 14 did not undergo any surgery during fosfomycin treatment. Fosfomycin was adminsitered parenterally, alone or combined with oral administration, and in some cases ...
J E, Fernandez-Valencia +3 more
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The revival of fosfomycin [PDF]
International Journal of Infectious Diseases, 2011 Fosfomycin, originally named phosphonomycin, was discovered in Spain in 1969. There are three forms of fosfomycin: fosfomycin tromethamine (a soluble salt) and fosfomycin calcium for oral use, and fosfomycin disodium for intravenous use. Fosfomycin is a bactericidal antibiotic that interferes with cell wall synthesis in both Gram-positive and Gram ...
Michalopoulos, Argyris S. +2 more
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Infectious Diseases and Therapy, 2023 Introduction High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE.
Tai-Chung Tseng +7 more
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Asp50Glu mutation in MurA results in fosfomycin resistance in Enterococcus faecium
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Enterococcus faecium is one of the important pathogens causing nosocomial infection, which can be resistant to fosfomycin by obtaining the plasmid-encoded fosfomycin resistance genes, and the mutation of MurA protein encoded by chromosome ...
Ling Xin +7 more
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Antibiotics, 2020 We investigated fosfomycin susceptibility in Escherichia coli clinical isolates from South Korea, including community-onset, hospital-onset, and long-term care facility (LTCF)-onset isolates.
Hyeri Seok +5 more
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Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance [PDF]
, 2020 Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess
Anderson, Rosaleen +8 more
core +2 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aim of this study was to investigate the mechanisms of fosfomycin resistance and epidemiological characteristics in fosfomycin-resistant enterococci in China.
Xiucai Zhang +6 more
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In vitro activity of fosfomycin against Campylobacter isolates from poultry and wild birds. [PDF]
PLoS ONE, 2018 Fosfomycin is a broad-spectrum antibiotic with the activity against both Gram-positive and Gram-negative pathogens by inhibiting the bacterial cell wall synthesis. Given the potential therapeutic efficacy of fosfomycin against Campylobacter spp., the aim
Bai Wei, Min Kang
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PLoS ONE, 2020 The effective treatment of carbapenemase-producing Klebsiella pneumoniae infection has been limited and required novel potential agents. Due to the novel drug development crisis, using old antimicrobial agents and combination therapy have been ...
Uthaibhorn Singkham-In +2 more
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