Experiences in fosfomycin susceptibility testing and resistance mechanism determination in Escherichia coli from urinary tract infections in the UK [PDF]
, 2018 PURPOSE: With an increase in the numbers of bacterial isolates resistant to first-line antibiotics, there has been a revival in the use of older drugs including fosfomycin with novel mechanisms of action.
Cottell, Jennifer L, Webber, Mark A
core +1 more source
Oral fosfomycin activity against Klebsiella pneumoniae in a dynamic bladder infection in vitro model
Journal of Antimicrobial Chemotherapy, 2022 Introduction The use of oral fosfomycin for urinary tract infections (UTIs) caused by non-Escherichia coli uropathogens is uncertain, including Klebsiella pneumoniae, the second most common uropathogen.
I. Abbott +6 more
semanticscholar +1 more source
Plasma and Urine Pharmacokinetics of Oral Fosfomycin Tromethamine in Dogs
Veterinary Sciences, 2023 Fosfomycin is a broad-spectrum, bactericidal antibiotic with low toxicity. It has been used in human medicine and is a promising candidate for treating infections in veterinary medicine.
Nattha Jariyapamornkoon +2 more
doaj +1 more source
Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]
, 2018 Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J. +2 more
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Fosfomycin resistance in community-acquired urinary pathogens from Western Cape, South Africa
Southern African Journal of Infectious Diseases, 2022 Oral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown.
L. Mosime, M. Newton-Foot, Pieter Nel
semanticscholar +1 more source
Proposing Kluyvera georgiana as the Origin of the Plasmid-Mediated Resistance Gene fosA4 [PDF]
, 2018 A putative fosA gene in Kluyvera georgiana 14751 showed 99% nucleotide identity with plasmid-encoded fosA4. Due to a single-nucleotide insertion translating to a truncated protein, K. georgiana 14751 fosA does not confer fosfomycin resistance.
Ghiglione, Barbara +4 more
core +1 more source
Antibiotics, 2022 Fosfomycin is currently a viable option against urinary tract infections, particularly against extended-spectrum β-lactamases (ESBL)-producing E. coli, due to its unique mechanism of action and its low resistance among bacteria.
Mario Galindo-Méndez +21 more
semanticscholar +1 more source
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2022 Introduction: Interest in fosfomycin, an old antibiotic, has been reignited because of the use of its intravenous formulation (fosfomycin sodium) in resistant infections.
Yakup GEZER +4 more
doaj +1 more source
Synergistic effect of fosfomycin and fluoroquinolones against Pseudomonas aeruginosa growing in a biofilm. [PDF]
, 2005 Ulifloxacin is the active form of the prodrug prulifloxacin and shows a highly potent antipseudomonal activity. In this study, we examined the combined effect of fosfomycin and ulifloxacin against Pseudomonas aeruginosa (P.
Hikida, Muneo +5 more
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The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model [PDF]
, 2012 There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens.
Alan Forrest +64 more
core +1 more source